Objective: To probe the therapeutic mechanism of Qiji Shenkang granule total polysaccharide on glomerular sclerosis by observing the effect of Qiji Shenkang granule total polysaccharide on the expression of interleukin-6 (IL-6)

monocyte chemoattractant protein-1 (MCP-1) of mesangial cells of rats. Method: Serum containing Qiji Shenkang granule total polysaccharide was collected by serum pharmacology method. The cultured rat glomerular mesangial cells were stimualted to proliferate by angiotensin II (Ang II). The protein expression of MCP-1 and IL-6 was measured by ELISA. Result: Qiji Shenkang granule total polysaccharide had markedly inhibitory effect on IL-6 with significant difference compared with the Ang II group (P<0.01). Qiji Shenkang granule total polysaccharide had remarkably inhibitory effect on MCP-1 with significant difference compared with the Ang II group (P<0.01). Conclusion: Qiji Shenkang granule total polysaccharide may inhibit the protein expression of IL-6 and MCP-1 to relieve the inflammatory reaction and thereby to prevent and treat glomerular sclerosis.