炎琥宁联合利巴韦林治疗手足口病的系统评价

罗钦宏; 古子娟; 梁锦枝; 方乙生

doi:10.11653/syfj2013130351

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炎琥宁联合利巴韦林治疗手足口病的系统评价

更新时间：2024-01-04

- 炎琥宁联合利巴韦林治疗手足口病的系统评价
- Systematic Review on Yanhuning Combined with Ribavirin in Treatment of Hand-food-mouth Disease
- 中国实验方剂学杂志 2013年19卷第13期页码：351-355
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013130351
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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罗钦宏, 古子娟, 梁锦枝, 等. 炎琥宁联合利巴韦林治疗手足口病的系统评价[J]. 中国实验方剂学杂志, 2013,19(13):351-355.

LUO Qin-hong, GU Zi-juan, LIANG Jin-zhi, et al. Systematic Review on Yanhuning Combined with Ribavirin in Treatment of Hand-food-mouth Disease[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 351-355.
罗钦宏, 古子娟, 梁锦枝, 等. 炎琥宁联合利巴韦林治疗手足口病的系统评价[J]. 中国实验方剂学杂志, 2013,19(13):351-355. DOI： 10.11653/syfj2013130351.

LUO Qin-hong, GU Zi-juan, LIANG Jin-zhi, et al. Systematic Review on Yanhuning Combined with Ribavirin in Treatment of Hand-food-mouth Disease[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 351-355. DOI： 10.11653/syfj2013130351.

摘要

目的:评价炎琥宁与利巴韦林治疗手足口病的疗效和安全性。方法:计算机检索Pubmed

CENTRAL

CBM

CNKI

VIP和万方等中英文数据库

纳入随机对照文献(RCT)

由两名评价员独立选择试验和评价质量后

提取有效数据进行Meta分析。结果:共纳入26个RCT

病例共3 571例。Meta分析结果显示

炎琥宁联合利巴韦林治疗手足口病在总有效率[OR=5.72

95%CI(4.17

7.85)]、退热时间[MD=-1.16

95%CI(-1.46

-0.85)]、疱疹消退时间[MD=-1.56

95%CI(-1.87

-1.25)]、溃疡消退时间[MD=-1.11

95%CI(-1.47

-0.75)]等方面均优于对照组(P<0.05)。结论:炎琥宁联合利巴韦林对治疗手足口病可能有一定疗效

但还需进行更多高质量的RCT才能对其疗效得出肯定性结论。

Abstract

Objective:To evaluate the effectiveness and safety of Yanhuning combined with and ribavir in treatment of the hand-foot-mouth disease. Method: Pubmed

CENTRAL

CBM

CNKI

VIP and Wanfang database were searched for clinical trials.Two evaluators chose trials and evaluated quality

valid data were put in Meta-analysis.Result:Twenty-six randomized clinical trials(RCT) and three thousand five hundred and seventy-one patiences were included. From the results of Meta-analysis

the effectiveness of Yanhuning combined with ribavirin was superior than the control group in the overall efficiency [OR=5.72

95%CI(4.17

7.85)]

defervescence time [MD=-1.16

95%CI(-1.46

-0.85)]

simplex subsiding time [MD=-1.56

95%CI(-1.87

-1.25)]

and ulcer subsiding time [MD=-1.11

95%CI(-1.47

-0.75)].Conclusion: It may have a certain effect on curing the hand foot mouth disease when Yanhuning combined with ribavirin. But we need more high-quality RCT to support our inference and make an exact conclusion for its efficacy.

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