白术生、制品对脾虚大鼠血清SS,GAS,CHE的影响

赵文龙; 杨彦华; 贾天柱

doi:10.11653/syfj2013140212

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白术生、制品对脾虚大鼠血清SS,GAS,CHE的影响

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- 白术生、制品对脾虚大鼠血清SS,GAS,CHE的影响
- Influence of Atractylodis Macrocephalae Rhizoma and Atractylodis Macrocephalae Rhizoma Fried with Bran on SS, GAS, CHE of in Rat Spleen Deficiency Model
- 中国实验方剂学杂志 2013年19卷第14期页码：212-215
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家行业专项基金(201107007)
- DOI：10.11653/syfj2013140212
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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赵文龙, 杨彦华, 贾天柱. 白术生、制品对脾虚大鼠血清SS,GAS,CHE的影响[J]. 中国实验方剂学杂志, 2013,19(14):212-215.

ZHAO Wen-long, YANG Yan-hua, JIA Tian-zhu. Influence of Atractylodis Macrocephalae Rhizoma and Atractylodis Macrocephalae Rhizoma Fried with Bran on SS, GAS, CHE of in Rat Spleen Deficiency Model[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 212-215.
赵文龙, 杨彦华, 贾天柱. 白术生、制品对脾虚大鼠血清SS,GAS,CHE的影响[J]. 中国实验方剂学杂志, 2013,19(14):212-215. DOI： 10.11653/syfj2013140212.

ZHAO Wen-long, YANG Yan-hua, JIA Tian-zhu. Influence of Atractylodis Macrocephalae Rhizoma and Atractylodis Macrocephalae Rhizoma Fried with Bran on SS, GAS, CHE of in Rat Spleen Deficiency Model[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 212-215. DOI： 10.11653/syfj2013140212.

摘要

目的: 研究白术生品及麸炒品对利血平所致脾虚模型大鼠生长抑素(SS)、胃泌素(GAS)、胆碱酯酶(CHE)的影响。方法: 将大鼠平均分成5组

即空白对照组

白术生品组

白术麸炒品组

阳性药莫沙必利组

模型组

每组10只

利血平0.5 mg·kg-1 sc 7 d复制大鼠脾虚模型。造模成功后

莫沙必利溶液按7 mL·kg-1(0.7 mg·kg-1)ig 7 d

白术生品、麸炒品水煎液20 g·kg-1 ig 7 d后取血清

测定大鼠血清中SS

GAS含量

CHE活力。结果: 与正常组比较模型组大鼠血清中SS

GAS含量显著降低

CHE活力显著升高(P<0.05);白术生品及麸炒组大鼠血清中CHE活力较模型组显著降低;SS

GAS含量与模型组相比有升高的趋势

总体麸炒白术作用优于生品。结论: 白术生品及白术麸炒品对利血平所致大鼠脾虚模型有较好的治疗作用。

Abstract

Objective: To study the influence of Atractylodis Macrocephalae Rhizoma and Atractylodis Macrocephalae Rhizoma fried with bran on somatostatin (SS)

gastrin (GAS)

cholinesterase (CHE)in rat spleen deficiency model. Method: The rats were divided into five groups

namely blank group

Atractylodis Macrocephalae Rhizoma raw group

Atractylodis Macrocephalae Rhizoma fried with bran group

positive drug group

model group

10 rats each group. Subcutaneous injection of reserpine was used to make rat spleen deficiency model

after modeling

the serum was separated

CHE activity

SS and GAS content were assayed. Result: In the model group

the content of SS

GAS in the serum was significantly reduced

CHE activity increased. The crude Atractylodis Macrocephalae Rhizoma and Atractylodis Macrocephalae Rhizoma with bran fried could decrease CHE activity;SS

GAS content increased compared with the model group. Conclusion: The raw Atractylodis Macrocephalae Rhizoma and Atractylodis Macrocephalae Rhizoma fried with bran have a better therapeutic effect.

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