Objective: To study synthesis and total antioxidant ability in vitro of menthyl Ferulate. Method: The vanillin was used as raw material and menthyl hydrogen malonate was used as intermediate

condensation reaction between them was used to synthesize menthyl ferulate

and the ferric reducing ability of plasma (FRAP) method was used to measure its total antioxidant ability in vitro. Result: Menthyl ferulate was obtained through three steps reaction route

this compound has not reported

its structure was confirmed by 1H-NMR and MS. Menthyl ferulate showed the antioxidant ability in the trial concentration range

but weak than ferulic acid. Conclusion: Menthyl ferulate has antioxidant activity

the synthetic method is applicable to other ferulic acid ester or ferulic acid amide derivatives.