Objective: To investigate the effect of Yiqi Yangxin decoction on brain natriuretic peptide(NT-proBNP) in plasma and inflammatory cell factor

tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) levels in patients with chronic heart failure(CHF) of Qi and Yin deficient type. Method: One hundred and twenty cases of CHF were equally divided into treatment group (60 cases) and control group (60 cases). The control group was given conventional western treatment

and the treatment group was used Yiqi Yangxin decoction for 4 weeks on the basis of the control group.The cardiac function

the level of NT-proBNP in plasma and the levels of TNF-α and IL-6 in serum were observed before and after treatment. Result: After 4 weeks treatment

the two groups cardiac function and left ventricular ejection fraction (LVEF) were obviously improved

and the levels of NT-proBNP in plasma and TNF-α and IL-6 in serum were obviously decreased;the decline degree of NT-proBNP in plasma and TNF-α and IL-6 in serum of treatment group after treatment was superior to the control group (P<0.05 or P<0.01). Conclusion: Yiqi Yangxin decoction could significantly improve cardiac function in patients with CHF

reduce the level of plasma NT-proBNP and the levels of TNF-α and IL-6 in serum.Its mechanism may be related to the inhibition of inflammatory cytokines to reduce the inflammatory response.