Objective: To compare the antihyperlipidemic and antioxidative effect of banana peel polyphenol and simvastatin. Method: Sixty rats were randomly divided into 6 groups

control group

model group

positive drug simvastatin group (10 mg·kg-1)

banana peel polyphenol low

middle and high dose group

(30

60

120 mg·kg-1)

10 rats in each group. Control group were fed with common food

the remaining 5 groups were intragastrically given high fat diet

banana peel polyphenol was administrated at the same timefor 40 days. Then the content of cholesterol(TC)

triglyceride(TG)

high density lipoprotein-cholesterol(HDL-C)

low density lipoprotein-cholesterol(LDL-C)

malondialdehyde(MDA) and the activity of the super oxide dismutase (SOD) in serum were determined. Result: Compared with the normal control group

the rats in the model group

serum TG

TC

LDL-C

MDA were significantly increased (P<0.05)

but the serum HDL-C

SOD

T-AOC activity was significantly decreased (P<0.05); compared with the model group

the banana peel polyphenols of low

middle and high dose group

serum TG

TC

LDL-C

MDA were decreased in different degree (P<0.05)

serum HDL-C

SOD and the activity of T-AOC increased significantly (P<0.05). Conclusion: Banana peel polyphenol has antihyperlipidemic and antioxidative effects on hyperlipidemic model rats.