Objective: To investigate the effect of Ziyin Qingre decoction on golden hamster in serum sex hormones and adnrogen receptor. Method: The animals were randomly divided into 4 groups

namely blank control group

positive control group

high and low dosage Ziyin Qingre decoction. Rats were respectively fed with saline solution

antisterone(10 mg·kg-1)

Ziyin Qingre decoction(18

9 g·kg-1) for 4 weeks. The serum testosterone(T) and estradiol(E2) levels were detected using enzyme-linked immunosorbant assay(ELISA) method. The gene androgen receptor(AR) mRNA in flank organ was measured by real-time PCR. Result: Compared with blank control group

high and low dosage Ziyin Qingre decoction could reduce serum T level and serum E2 level(P<0.05).There was a difference between four groups in expressions of AR mRNA(P<0.05). The AR mRNA in high dosage group was decreased(P<0.05)

compared to the blank control group. Conclusion: Ziyin Qingre decoction can increase the serum E2 level and suppress the expression of AR mRNA. These may affect the proliferation of sebaceous gland.