四逆汤组方不同配伍毒效关系研究

杨海润; 孙建宁; 张广平; 朱晓光; 张思玉; 解素花

doi:10.11653/syfj2013230266

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四逆汤组方不同配伍毒效关系研究

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- 四逆汤组方不同配伍毒效关系研究
- Study on the Effect and Toxicity of Sini Decoction Formula from the Different Compatibility Prescription
- 中国实验方剂学杂志 2013年19卷第23期页码：266-269
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- DOI：10.11653/syfj2013230266
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- 纸质出版日期：2013
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杨海润, 孙建宁, 张广平, 等. 四逆汤组方不同配伍毒效关系研究[J]. 中国实验方剂学杂志, 2013,19(23):266-269.

YANG Hai-run, SUN Jian-ning, ZHANG Guang-ping, et al. Study on the Effect and Toxicity of Sini Decoction Formula from the Different Compatibility Prescription[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 266-269.
杨海润, 孙建宁, 张广平, 等. 四逆汤组方不同配伍毒效关系研究[J]. 中国实验方剂学杂志, 2013,19(23):266-269. DOI： 10.11653/syfj2013230266.

YANG Hai-run, SUN Jian-ning, ZHANG Guang-ping, et al. Study on the Effect and Toxicity of Sini Decoction Formula from the Different Compatibility Prescription[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 266-269. DOI： 10.11653/syfj2013230266.

摘要

目的: 从药效和毒性两个方面对于四逆汤处方配伍进行研究，为四逆汤复方配伍的合理性提供实验依据。方法: 平行比较附子、四逆汤全方、附子配伍甘草、附子配伍干姜对小鼠急性毒性，测定其半数致死剂量（LD50）。开展了附子、四逆汤全方、附子配伍甘草、附子配伍干姜对阿霉素导致大鼠心衰模型影响研究，观察了受试物对心衰大鼠颈总动脉血流量、心率（HR）、左室收缩压（LVSP）、左室舒张末压（LVEDP）、左室内压力上升的最大速率（+dp/dtmax）及左室内压力下降的最大速率（-dp/dtmax）的影响。结果: 急性毒性实验结果显示，四逆汤处方配伍中附子配伍甘草对附子的减毒作用要优于附子配伍干姜，在减毒方面甘草起主要作用。四逆汤对阿霉素导致大鼠心衰模型试验结果显示，四逆汤全方、附子配伍甘草、附子配伍干姜和单用附子药效作用相似，均是通过增加心率、提高LVSP、增加+dp/dtmax，提高颈动脉血液流量起到治疗作用。附子配伍干姜对于附子的药效促进作用优于甘草，在增加处方药效方面干姜起主要作用。结论: 四逆汤组方中甘草在减低处方的毒性方面起主要作用，干姜在增强附子药效方面起主要作用，从药效和毒性两方面阐明四逆汤处方配伍规律的合理性。

Abstract

Objective: To provide rationality of Sini decoction compound compatibility based on the toxicity and efficacy. Method: To compare the acute toxicity between the aconite group

Sini decoction group

Aconiti Lateralis Radix Praeparata combined with Glycyrrhizae Radix et Rhizoma group and Aconiti Lateralis Radix Praeparata combined with Zingiberis Rhizoma group

and the median lethal dose (LD50) was determined. To study the effect of the four above mentioned groups the rat heart failure model was induced by adriamycin

and the icarotid artery blood flow

heart rate (HR)

left ventricular systolic pressure (LVSP)

left ventricular end-diastolic pressure(LVEDP)

left ventricular maximum rate of pressure rise(+dp/dtmax) and left ventricular minimum rate of pressure drop (-dp/dtmax)were observed. Result: The result of the acute toxicity experiment showed that in Sini decotion prescription

the attenuation of Aconiti Lateralis Radix Praeparata combined with Glycyrrhizae Radix et Rhizoma group was better than Aconiti Lateralis Radix Praeparata combined with Zingiberis Rhizoma.The experimental results on the effects of Sini decotion showed that Sini decotion group

Aconiti Lateralis Radix Praeparata combined with Glycyrrhizae Radix et Rhizoma group

Aconiti Lateralis Radix Praeparata combined with Zingiberis Rhizoma and the single Aconiti Lateralis Radix Praeparata group had same effects like increasing the LVSP

the+dp/dtmax and the blood output. The effect of Aconiti Lateralis Radix Praeparata combined with Zingiberis Rhizoma was better than Aconiti Lateralis Radix Praeparata combined with Glycyrrhizae Radix et Rhizoma

Zingiberis Rhizoma plays a main role in it. Conclusion: In the prescription compatibility of Sini decocion Glycyrrhizae Radix et Rhizoma plays a main role in the attenuation of toxicity and Zingiberis Rhizoma plays a main role in efficacy

these results illuminate the rationality of Sini decoction compatibility

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