Objective: To optimize formulation process of dispersible tablets of Bauhinia championi and establish its quality control method. Method: Taking disintegration time as index

central composite design and response surface methodology was adopted to optimize preparation process of dispersible tablets with amounts of MCC

L-HPC and PVPP as factors;HPLC was used to determine contents of 3'

4'

5'

5

7-pentamethoxyflavone and 3'

4'-methylenedioxy-5'

5

6

7-tetramethoxyflavone by taking acetonitrile(A)-water(B)(0-20 min

30%-40%A;20-36 min

40%-48%A) as mobile phase

detection wavelength was 324 nm

then in vitro dissolution of dispersible tablets was investigated. Result: Optimal prescription was as following:MCC 58%

L-HPC 9.2%

PVPP 9.8%

magnesium stearate 1.0%;Disintegration time of dispersible tablets was 40 s and its in vitro dissolution was more than 90% within 30 min. Conclusion: These prepared dispersible tablets of B. championi had characteristics of fast disintegrating profile and high dissolution

which was suitable for clinical needs.