黄连-黄芩药对在泻心汤和葛根芩连汤组方配伍中主要成分的含量变化

邬玉玉; 袁慧雅; 陈晓辉; 毕开顺; 李伟

doi:10.11653/syfj2014060091

您当前的位置：

首页 >

文章列表页 >

黄连-黄芩药对在泻心汤和葛根芩连汤组方配伍中主要成分的含量变化

更新时间：2024-01-04

- 黄连-黄芩药对在泻心汤和葛根芩连汤组方配伍中主要成分的含量变化
- Content Change of Main Components of Coptis Rhizome and Scutellaria Radix Couples among Different Compatibilities of Medicinal Materials in Xiexin Decoction and Gegen Qinlian Decoction
- 中国实验方剂学杂志 2014年20卷第6期页码：91-95
- 作者机构：
- 作者简介：
- 基金信息：
  
  2012年辽宁省高等学校中药质量控制关键技术创新团队项目（LT2012018）
- DOI：10.11653/syfj2014060091
  中图分类号：
- 纸质出版日期：2014
- 稿件说明：
移动端阅览
邬玉玉, 袁慧雅, 陈晓辉, 等. 黄连-黄芩药对在泻心汤和葛根芩连汤组方配伍中主要成分的含量变化[J]. 中国实验方剂学杂志, 2014,20(6):91-95.

WU Yu-yu, YUAN Hui-ya, CHEN Xiao-hui, et al. Content Change of Main Components of Coptis Rhizome and Scutellaria Radix Couples among Different Compatibilities of Medicinal Materials in Xiexin Decoction and Gegen Qinlian Decoction[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 91-95.
邬玉玉, 袁慧雅, 陈晓辉, 等. 黄连-黄芩药对在泻心汤和葛根芩连汤组方配伍中主要成分的含量变化[J]. 中国实验方剂学杂志, 2014,20(6):91-95. DOI： 10.11653/syfj2014060091.

WU Yu-yu, YUAN Hui-ya, CHEN Xiao-hui, et al. Content Change of Main Components of Coptis Rhizome and Scutellaria Radix Couples among Different Compatibilities of Medicinal Materials in Xiexin Decoction and Gegen Qinlian Decoction[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 91-95. DOI： 10.11653/syfj2014060091.

摘要

目的：探索药对黄连-黄芩在泻心汤和葛根芩连汤组方不同配伍情况下其中所含小檗碱、巴马汀、黄芩苷、黄芩素、汉黄芩素的含量变化。方法：采用HPLC以乙腈-10 mmol·mL-1甲酸铵溶液（内含0.2%三乙胺，用甲酸调pH到4.00）为流动相进行梯度洗脱。结果：组方中黄芩、大黄、甘草使黄连中小檗碱、巴马汀含量降低，葛根使小檗碱、巴马汀含量增加。组方配伍中黄连使黄芩中黄酮类成分含量降低，大黄和甘草对黄芩苷含量的影响无显著性差异，但使黄芩素、汉黄芩素含量降低；葛根使黄芩苷含量降低，但使黄芩素、汉黄芩素含量增加。结论：该方法可以有效鉴定泻心汤和葛根汤中5种成分，不同配伍对5种有效成分含量有影响增加。

Abstract

Objective: To explore the change of content of berberine

palmatine

baicalin

baicalein

wogonin of and Scutellaria Radix couples among different compatibilities of medicinal materials in Xiexin decoction Coptis Rhizome and and Gegen Qinlian decoction. Method: By HPLC

mobile phase was acetonitrile-0.01 mol·L-1 ammonium formate (contain 0.2% triethylamine and adjusted pH to 4.00 with formic acid) in gradient elution. Result: The content of berberine

palmatine of Coptis Rhizome was decreased by Scutellaria Radix

Rhei Radix et Rhizoma and Glycyrrhizae Radix et Rhizoma among different medicinal materials. The content of berberine

palmatine was increased by Puerariae Lobatae Radix. The content of flavonoids of Scutellaria Radix was reduced by Coptis Rhizome. It was insignificant to the difference on the content of baicalin caused by Rhei Radix et Rhizoma and Glycyrrhizae Radix et Rhizoma which decreased the content of baicalein

wogonin. The content of baicalin was reduced by Puerariae Lobatae Radix which caused the increase of content of baicalein and wogonin. Conclusion: Five effective components were influenced by different compatibilities of medicinal materials in Xiexin decoction and Gegen Qinlian decoction.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

地黄块根中药效成分“配伍”特征及清热凉血功效

麻黄、细辛、附子配伍对过敏性鼻炎模型小鼠肺ILC2s相关因子的影响

上二黄丸通过调节胆汁酸代谢促进功能性便秘大鼠肠动力的配伍机制

基于超分子体系探究矿物药龙骨在含柴胡的角药配伍中的作用机制

基于代谢组学的四逆汤中附子-干姜药对配伍前后毒效变化规律分析