草乌及其炮制品中6种生物碱类成分的含量测定

邓广海; 林华; 龚又明

doi:10.11653/zgsyfjxzz2013070035

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草乌及其炮制品中6种生物碱类成分的含量测定

更新时间：2024-01-04

- 草乌及其炮制品中6种生物碱类成分的含量测定
- Content Determination of Six Kinds of Alkaloids from and Its Processed Products
- 中国实验方剂学杂志 2013年19卷第7期页码：35-38
- 作者机构：
- 作者简介：
- 基金信息：
  
  广东省科技厅资助项目(2009B030801300)
- DOI：10.11653/zgsyfjxzz2013070035
  中图分类号：
- 纸质出版日期：2013
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邓广海, 林华, 龚又明. 草乌及其炮制品中6种生物碱类成分的含量测定[J]. 中国实验方剂学杂志, 2013,19(7):35-38.

DENG Guang-hai, LIN Hua, GONG You-ming. Content Determination of Six Kinds of Alkaloids from and Its Processed Products[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 35-38.
邓广海, 林华, 龚又明. 草乌及其炮制品中6种生物碱类成分的含量测定[J]. 中国实验方剂学杂志, 2013,19(7):35-38. DOI： 10.11653/zgsyfjxzz2013070035.

DENG Guang-hai, LIN Hua, GONG You-ming. Content Determination of Six Kinds of Alkaloids from and Its Processed Products[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 35-38. DOI： 10.11653/zgsyfjxzz2013070035.

摘要

目的: 测定不同产地草乌及草乌炮制品中6种生物碱的含量

综合评价其安全性和有效性。方法: 采用HPLC同时测定6种生物碱含量

比较草乌炮制前后有效成分含量变化。结果: 草乌生品中单酯型生物碱含量0.408 1～1.718 2 mg·g-1

双酯型生物碱含量0.660 4～8.653 2 mg·g-1;炮制后双酯型生物碱大大减少

而单酯型生物碱则明显增加。结论: 不同产地草乌中6种生物碱的含量差异较大

常压蒸、煮法具有一定科学性

炮制后双酯型生物碱<0.04%

而单酯型生物碱常超出限量要求。

Abstract

Objective: To determine the contents of six kinds of alkaloids from Aconitum kusnezoffii and its processed products

evaluate its safety and effectiveness of clinical application. Method: The contents of six kinds of alkaloids was determined simultaneously by HPLC

and compare content changes of six kinds of alkaloid before and after processing. Result: The content of monoester alkaloids from A. kusnezoffii was 0.408 1-1.718 2 mg·g-1

and the content of diesterifiable alkaloids was 0.660 4-8.653 2 mg·g-1;The content of diesterifiable alkaloids greatly reduced and the content of monoester alkaloids increased significantly after processing. Conclusion: The content of six kinds of alkaloid had significantly difference from A. kusnezoffii in different areas

processing technologies of steam and cooking had some scientific

the content of diesterifiable alkaloids was less than 0.04% and monoester alkaloids often beyond limited demand after processing.

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