Box-Behnken效应面法优化菊花提取工艺

张建萍

doi:10.13422/j.cnki.syfix.2014080036

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Box-Behnken效应面法优化菊花提取工艺

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- Box-Behnken效应面法优化菊花提取工艺
- Optimization of Extraction Process of Chrysanthemi Flos by Box-Behnken Response Surface Methodology
- 中国实验方剂学杂志 2014年20卷第8期页码：36-40
- 作者机构：
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- 基金信息：
  
  济南军区后勤科研计划项目（CJN10L067）
- DOI：10.13422/j.cnki.syfix.2014080036
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- 纸质出版日期：2014
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张建萍. Box-Behnken效应面法优化菊花提取工艺[J]. 中国实验方剂学杂志, 2014,20(8):36-40.

ZHANG Jian-ping. Optimization of Extraction Process of Chrysanthemi Flos by Box-Behnken Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(8): 36-40.
张建萍. Box-Behnken效应面法优化菊花提取工艺[J]. 中国实验方剂学杂志, 2014,20(8):36-40. DOI： 10.13422/j.cnki.syfix.2014080036.

ZHANG Jian-ping. Optimization of Extraction Process of Chrysanthemi Flos by Box-Behnken Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(8): 36-40. DOI： 10.13422/j.cnki.syfix.2014080036.

摘要

目的：优选菊花的提取工艺条件。方法：选择提取时间、乙醇体积分数、加醇量为自变量，木犀草素、芹菜素、绿原酸得率的总评“归一值”为因变量，采用Box-Behnken效应面法优选菊花的醇提工艺并对该工艺进行预测分析。结果：最佳提取工艺为加12倍量80%乙醇提取110 min；木犀草素、芹菜素、绿原酸平均得率分别为1.64%，0.94%，3.95%，实测OD=0.979 6（RSD 1.83%），与预测值（0.981 6）的偏差0.204%。结论：优选的提取工艺稳定可行且可预测性强。

Abstract

Objective: To optimize extraction process of Chrysanthemi Flos. Method: Based on single factor test

taking extracting time

ethanol concentration and amount as independent variables

overall desirability(OD) of yield of luteolin

apigenin and chlorogenic acid as dependent variable

Box-Behnken response surface methodology was applied to optimize extraction conditions. Result: Optional extraction process was as follows:extracted 110 min with 12 times the amount of 80% ethanol;Average yields of luteolin

apigenin and chlorogenic acid were 1.64%

0.94% and 3.95%

respectively

deviation between the measured value(0.979 6) and the predicted value(0.981 6) of OD was 0.204%. Conclusion: This optimized extaction technology was simple and reliable with high predictability.

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