Objective:To explore rat model of type 2 diabetes macroscopic characterization

rectal temperature

grip and related biochemical parameters

in order to explore mechanisms of Gegen Qinlian decoction in treatment of type 2 diabetes. Method:Fat diet combined with streptozotocin(STZ) were used to induce type 2 diabetes model

Gegen Qinlian decoction 9.1 g·kg-1 (GGQL1)

18.2 g·kg-1 (GGQL2) were given. The macroscopic characterization

rectal temperature

grip and related biochemical markers were observed. Result:After administration

in GGQL1 group the blood glucose was lower (P<0.05)

the diet consume was reduced(P<0.05); in GGQL2 group

the blood glucose was lower (P<0.05)

the food intake was reduced

grip force value was increased (P<0.05)

triglycerides(TG) was decreased (P<0.05); GGQL1

GGQL2 could reduce activity

grasping take revolt

dark glazed eyes

less gloss lip does not run

tongue less fluid

less shiny nose does not run

hair drying. Conclusion:Gegen Qinlian decoction can maintain body weight

reduce fasting blood glucose

reduce food intake and increase grip and reduce TG

improve symptoms of fatigue

body fluid deficiency in type 2 diabetic rats.