Objective: To optimize preparation technology of intermediates of Ruxiankang injections. Method: With composite score of contents of total solids and hesperidin as index

orthogonal test and single factor test were adopted to investigate effects of extracting time

extraction times

ethanol concentration and amount on technology of Glycyrrhizae Radix et Rhizoma and Citri Reticulatae Pericarpium Viride.Taking contents of total flavonoids and solids as comprehensive evaluation index

effects of the amount of water

extracting time and times on extraction process of Taraxaci Herba was investigated by orthogonal test

single factor test was adopted to optimize alcohol precipitation process.HPLC was employed to determine the content of hesperidin with mobile phase of methanol-water(50:50) and detection wavelength at 284 nm. Result: Optimum extraction technology of Glycyrrhizae Radix et Rhizoma and Citri Reticulatae Pericarpium Viride was as following:extracted 3 times with 6 times the amount of 60% ethanol for 2 h each time.Optimum extraction process of Taraxaci Herba was adding 16 times the amount of water for soaking 0.5 h

extracted 3 times with 0.5 h for each time.Extract was concentrated under vacuum to a relative density of 1.15-1.25(60-80 ℃)

added 95% ethanol slowly to ethanol amount of 85%

recovered ethanol to a relative density of 1.25(60-80 ℃). Conclusion: These optimized processes were stable and feasible

it could provide a reference for preparation of Ruxiankang injections.