Objective: To investigate the a

ntidepressant-like effects of Gardenia jasminoides fruit (GJF) and Lycium barbarum fruit (LBF) compatibility. Method: Mice were treated with different ratios of GIF and LBF (BMGL)

and fluoxetine hydrochloride (FH

10 mg·kg-1) was given everyday for 7 days by intragastric administration (ig). The mouse forced swim test (FST)

tail suspension test (TST)

open field test (OFT) and reserpine reversal test (RRT) were used to observe antidepressant effects of BMGL

respectively

at 1 h after the last administration. Result: The immobility time in TST and FST in model mice was (85.1±21.9)

(95.6±25.3) s respectively

and the body temperature in model mice was (34.7±0.9)℃. There was significant decrease among different ratios of BMGL (3 g·kg-1) and FH (10 mg·kg-1) groups compared with model group. The numbers of crossing squares in 3 min in model mice during OFT was 105.6±28.3

and there was no significant difference among BMGL (3 g·kg-1) and FH (10 mg·kg-1) groups compared with model group. Conclusion: BMGL exerts antidepressant effect with compatibility ratio of GJF and LBF being from 1:4 to 2:1

and the mechanism may be involved in monoaminergic nervous systems.