林蛙油对运动训练大鼠睾酮含量、物质代谢及抗运动疲劳能力的影响

娄春善; 曹建民; 郭娴; 周海涛; 商晓绪

doi:10.13422/j.cnki.syfjx.2014200150

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林蛙油对运动训练大鼠睾酮含量、物质代谢及抗运动疲劳能力的影响

药理 | 更新时间：2024-01-04

- 林蛙油对运动训练大鼠睾酮含量、物质代谢及抗运动疲劳能力的影响
- Effect of Oviductus Ranae on Testosterone Content, Substance Metabolism and Exercise Capacity in Rats Receiving Exercise Training
- 中国实验方剂学杂志 2014年20卷第20期页码：150-154
- 作者机构：
- 作者简介：
- 基金信息：
  
  河北省教育厅重点资助项目（ZD20131100）
- DOI：10.13422/j.cnki.syfjx.2014200150
  中图分类号： R285.5
- 纸质出版日期：2014
- 稿件说明：
移动端阅览
娄春善, 曹建民, 郭娴, 等. 林蛙油对运动训练大鼠睾酮含量、物质代谢及抗运动疲劳能力的影响[J]. 中国实验方剂学杂志, 2014,20(20):150-154.

LOU Chun-shan, CAO Jian-min, GUO Xian, et al. Effect of Oviductus Ranae on Testosterone Content, Substance Metabolism and Exercise Capacity in Rats Receiving Exercise Training[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(20): 150-154.
娄春善, 曹建民, 郭娴, 等. 林蛙油对运动训练大鼠睾酮含量、物质代谢及抗运动疲劳能力的影响[J]. 中国实验方剂学杂志, 2014,20(20):150-154. DOI： 10.13422/j.cnki.syfjx.2014200150.

LOU Chun-shan, CAO Jian-min, GUO Xian, et al. Effect of Oviductus Ranae on Testosterone Content, Substance Metabolism and Exercise Capacity in Rats Receiving Exercise Training[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(20): 150-154. DOI： 10.13422/j.cnki.syfjx.2014200150.

摘要

目的：研究林蛙油对运动训练大鼠睾酮含量、物质代谢及抗运动疲劳能力的影响。方法：以大强度耐力训练大鼠为模型，55只42 d龄雄性Wistar大鼠为对象，随机分为5组：静止对照组（C组）、运动对照组（M组）、运动+低剂量林蛙油组（OML组），运动+中剂量林蛙油组（OMM组），运动+高剂量林蛙油组（OMH组），每组10只（剔除不符合实验要求的大鼠5只）。每天灌胃（ig）1次，林蛙油组剂量分为0.5，1.0，3.0 g ·kg-1，灌胃体积为5 mL ·kg-1，C，M组ig等量生理盐水。42 d力竭游泳训练后，测定体重、力竭游泳时间及血睾酮等生化指标。结果：体重：运动对照组小于静止对照组（P<0.05）；林蛙油各组大于运动对照组（P<0.05），组间无显著差异。力竭游泳时间：运动对照组与静止对照组无明显差异；林蛙油各组明显长于运动对照组（P<0.01），且随剂量增大而延长。血清睾酮水平：运动对照组（P<0.01）低于静止对照组；林蛙油各组分别为（4.96±1.60），（5.19±1.60），（5.35±1.66） nmol ·L-1，高于运动对照组（P<0.01），组间无显著差异。血清皮质酮水平：各组间均无显著差异。血清睾酮与皮质酮比值变化与睾酮变化较为一致。肝、肌糖原水平：运动对照组（P<0.01）低于静止对照组；林蛙油各组高于运动对照组（分别为P<0.05，P<0.01），组间无显著差异。促黄体生成素、促卵泡激素各组间无显著差异。血尿素水平：运动对照组（P<0.01）高于安静对照组；林蛙油各组低于运动对照组（P<0.01），且组间无显著差异。血红蛋白水平：运动对照组（P<0.01）低于静止对照组；林蛙油各组高于运动对照组（P<0.01），且组间无显著差异。结论：林蛙油可以减轻血睾酮受高强度运动量的影响，并维持在正常生理水平；可以促进蛋白质合成，抑制氨基酸和蛋白质分解，提高运动训练大鼠血红蛋白含量和糖原的储备。

Abstract

Objective: To study the effects of Oviductus Ranae on the content of testosterone

substance metabolism and anti-fatigue ability of rats after exercise. Method: By using the model of high-intensity endurance training

fifty-five male Wistar rats were randomly divided into 5 groups

with 10 in each group. The rats which did not meet the requirement were removed:still in control group (C group)

motion control group (M group)

exercise +ig low-dose Oviductus Ranae group (OML group)

exercise+ig middle-dose Oviductus Ranae group (OMM group)

and exercise+ig high-dose Oviductus Ranae group (OMH group). Gavage was performed using professional device once a day. The rats in Oviductus Ranae groups were gavaged with 0.5

1.0

3.0 g·kg-1 with ig volume of 5 mL·kg-1. The rats in C and M groups were given saline of same volume. After 42 days of exhaustive swimming training

body weight

swimming time and serum testosterone and other biochemical markers were measured. Result: The body weights of the rats in M groups were lower than those in C group (P<0.05)

and those in all doses of Oviductus Ranae groups were higher than in M group (P<0.05) which showed no differences between groups. Swimming time in all doses of Oviductus Ranae groups was longer than M group (P<0.01)with a dose-effect relationship

But there were no differences between C and M groups. Serum testosterone in M group was lower than C group (P<0.01)

in the same time

serum testosterone was higher in all doses of Oviductus Ranae groups than M group [OML:(4.96±1.60) nmol·L-1;OMM:(5.19±1.60) nmol·L-1;OMH:(5.35±1.66) nmol·L-1

P<0.01]. The serum corticosterone levels in each group showed no significant differences. Changes in the ratio of serum testosterone/corticosterone were more consistent with testosterone changes among the groups. Liver glycogen and muscle glycogen (P<0.01) in M group were lower than in C group

and in all doses of Oviductus Ranae groups were higher than in M group (liver glycogen

P<0.05;muscle glycogen

P<0.01). There were no differences in luteinizing hormone and follicle-stimulating hormone between groups. The serum urea nitrogen in M group was higher than C group (P<0.01)

and in all doses of Oviductus Ranae groups was lower than the M group (P<0.01). Hemoglobin in M group was lower than C group (P<0.01)

and in all doses of Oviductus Ranae groups were higher than in M group(P<0.01). Conclusion: Oviductus Ranae can alleviate the impact of high-intensity exercise on serum testosterone

and maintained it at normal physiological levels;it can also promote protein synthesis

inhibit degradation of amino acid and protein

and increase hemoglobin and glycogen reserves in rats exercise training.

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