Objective: To observe the clinical efficacy of Bushen Tiaojing decoction in treating patients with premature ovarian failure (POF)

and its effect on reproductive axis. Method: Ninty-six patients with POF were divided into three groups by a random number table. Patients in traditional Chinese medicine (TCM) group (32 cases) took Bushen Tiaojing decoction

patients in western medicine (WM) group (32 cases)took hormone replacement therapy (HRT)

Chinese and Western medicine (CWM) group (32 cases)took Bushen Tiaojing decoction plus HRT. All patients in three groups received six 4-week or six 1-month periods of treatment and 3-months follow-up after treatment. The clinical efficacy

clinical symptom score and serum sex hormones levels [estradiol(E2)

follicle stimulating hormone(FSH)

luteinizing hormone (LH)]and recurrence rate in three groups were compared before and after treatment

and after 3-months withdrawal. Result: The total effective rate of TCM group

WM group and CWM group were 83.3%

70% and 93.3% with statistically significant difference among three groups (P<0.05). At the end of treatment and withdrawal of 3 months

clinical symptom scores in TCM and CWM groups were better than that in WM group (P<0.05

P<0.01). At the end of treatment and withdrawal of 3 months

the improvement in blood E2

FSH

LH and FSH/LH levels in TCM and CWM groups were better than that in WM group (P<0.05

P<0.01). The improvement in the situation and time of menses in CWM group were better than that in TCM and WM groups (P<0.05)

and recurrence rate in TCM and CWM groups was lower than that in WM group (P<0.05). Conclusion: Bushen Tiaojing decoction can improve the clinical symptoms of patients with POF

restore normal menstruation and regulate serum sex hormones levels. Morover

it had low recurrence rate and fewer adverse reactions. Its mechanism may be achieved by regulating the reproductive axis of Kidney-Tiangui-Chongren-Uterus of traditional Chinese medicine theory.