Objective: To investigate the effect of Shenlin Baishu San on the dysbacteriosis induced by antibiotics in mice. Method: The healthy SPF BALB/c mice were divided into the normal group

the model control group

the Peifeikang group (0.1 g·kg-1) and the low-

medium-

high-dose Shenlin Baishu San groups (0.1

0.2

0.4 g·kg-1). Dysbacteriosis models were induced by antibiotics ceftriaxone sodium solution for 5 days. After 7-day treatment

changes of intestinal flora with sterile take feces were observed using plate dilution method (each intestinal bacteria number was trained). Serum immunoglobulin G (IgG)

endotoxin

vasoactive intestinal peptide (VIP) and substance P (SP) content were measured using enzyme linked immunosorbent assay. Result: The number of probiotics in the model group was signifigantly decreased as compared with that in the normal group (P<0.01). Serum levels of endotoxin and SP were significantly higher. serum IgG and VIP were significantly lower in model group than those in control group (P<0.01). The bacteria number

endotoxin

VIP and SP were decreased

serum IgG was increased in all dosages of Shenlin Baishu San groups

there was statistically significant difference as compared with model group (P<0.05

P<0.01). Conclusion: Shenlin Baishu San could regulate the balance of intestinal flora effectively.