芫花甘草不同配伍比例的HPLC指纹图谱探讨

王亮; 张振秋; 邓仕任; 夏林波

doi:10.13422/j.cnki.syfjx.2015020080

您当前的位置：

首页 >

文章列表页 >

芫花甘草不同配伍比例的HPLC指纹图谱探讨

化学与分析 | 更新时间：2024-01-04

- 芫花甘草不同配伍比例的HPLC指纹图谱探讨
- Research About HPLC Firgerprints of Genkwa Flos and Glycyrrhizae Radix with Different Compatibility Poroportion
- 中国实验方剂学杂志 2015年21卷第2期页码：80-82
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015020080
  中图分类号： R284.1
- 纸质出版日期：2015
- 稿件说明：
移动端阅览
王亮, 张振秋, 邓仕任, 等. 芫花甘草不同配伍比例的HPLC指纹图谱探讨[J]. 中国实验方剂学杂志, 2015,21(2):80-82.

WANG Liang, ZHANG Zhen-qiu, DENG Shi-ren, et al. Research About HPLC Firgerprints of Genkwa Flos and Glycyrrhizae Radix with Different Compatibility Poroportion[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(2): 80-82.
王亮, 张振秋, 邓仕任, 等. 芫花甘草不同配伍比例的HPLC指纹图谱探讨[J]. 中国实验方剂学杂志, 2015,21(2):80-82. DOI： 10.13422/j.cnki.syfjx.2015020080.

WANG Liang, ZHANG Zhen-qiu, DENG Shi-ren, et al. Research About HPLC Firgerprints of Genkwa Flos and Glycyrrhizae Radix with Different Compatibility Poroportion[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(2): 80-82. DOI： 10.13422/j.cnki.syfjx.2015020080.

摘要

目的: 通过研究芫花甘草不同配伍比例的HPLC指纹图谱

探讨其化学成分的相互作用及变化趋势。方法: 采用 HPLC 对芫花甘草不同配伍比例的指纹图谱进行比较

并用HPLC-ESI-MS 对共有峰进行初步归属。结果: 芫花甘草不同比例配伍对其中化学成分的溶出具有一定的规律性。随甘草比例升高

芹糖甘草苷、芹菜素5-O-β-D葡萄糖苷、芹糖异甘草苷、羟基芫花素、甘草酸的溶出降低;芹菜素-7-O-β-D-葡萄糖醛酸苷

在1:1配伍比例中溶出最多。结论: 芫花甘草配伍后成分的溶出降低

从而可能降低其药理作用

从化学成分角度研究评价中药配伍禁忌提供思路和方法。

Abstract

Objective: To investigate the interaction and changing trend of chemical composition in eighteen incompatible medicaments

Genkwa Flos and Glycyrrhizae Radix

with different compatibility using HPLC fingerprints. Method: The fingerprints of Genkwa Flos and Glycyrhizae Radix with different compatibility proportion were analyzed by HPLC. Characteristic peaks were identified preliminarily based on the MS spectra and literature data. Result: The dissolution of liquiritin apioside

apigenin-5-O-β-D-glucoside

isoliquiritin apioside

hydroxy-genkwanin and glycyrrhizic acid were reduced with increase the proportion of Glycyrhizae Radix. The dissolution of apigenin-7-O-β-D-glucuronide was reached the maximum value at 1:1 compatibility proportion. Conclusion: The dissolution of Genkwa Flos and Glycyrrhizae Radix reduced

thus may reduce its pharmacological action

provide the mentality and the method of evaluation of traditional Chinese medicine incompatibility from chemical angle.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

小白及高效液相指纹图谱分析

不同果形栀子鲜品不同极性部位HPLC指纹图谱

苦杏仁中苦杏仁甙的含量测定

HPLC法测定强力枇杷露中可待因的含量