Objective: To investigate the antithrombotic effect and the mechanism of the thrombolysis effect of mongolian medicine Zhachong Shisan Wei pill. Method: The rats were randomly divided into 5 groups:control group

Zhachong Shisan Wei pill in high

middle and low dose (1.728

0.864

0.432 g · kg-1)groups

and compound Danshen dripping pills treatment group with 0.12 g · kg-1.The effects of Zhachong Shisan Wei pill on the formation of thrombus in rats were observed through the way of arteriovenous loop. The dissolution percentage of thrombus in vitro was measured. The fibrinogen degradation product (FDP) of rat at different time after administration was studied in vivo. Result: Compared with the model group

Zhachong Shisan Wei pill with different dose could significantly decrease the weight of thrombus (P<0.001)

the length of thrombus (P<0.05

P<0.001).Model group increased the content of FDP compared with the control group. Compared with model group

effect of Zhachong Shisan Wei pill on the FDP content of the thrombus degradation products was decreased(P < 0.05). Conclusion: Zhachong Shisan Wei pill have significant antithrombotic and thrombolysis effects in vivo and in vitro. Degradation of fibrin is one of the mechanisms of antithrombotic and thrombolysis.