Objective: To study the effect of Baoxin pill on liver function in the rabbit with dilated cardiomyopathy (DCM). Method: Seventy-two rabbits were randomly divided into the normal group

the model group

the high-

medium-

low-dose Baoxin pill groups (2.7

1.35

0.675 g · kg-1)

and the captopril group (2.5 mg · kg-1). The DCM model was induced in rabbits by injecting doxorubicin (0.75 mg · kg-1) via the ear vein twice weekly for 4 weeks. The heart rate

aortic dimension

left ventricular and diastolic diameter

left ventricular and systolic diameter were measured

and the left ventricular ejection fraction (LVEF) and the stroke volume (SV) were calculated at the fourth week. After continuous intragastric administration of the corresponding medicines for 30 days

the levels of alanine aminotransferase (ALT)

aspartate aminotransferase (AST)

alkaline phosphatase (ALP)

γ-glutamyltransferase (γ-GT)

total protein (TP)

albumin (ALB)

creatine kinase (CK) were measured at the eighth week. The pathological changes of heart tissue were observed by HE staining. Result: Compared with normal group

the LVEF and SV decreased at the fourth week

the levels of ALT

AST

γ-GT

ALB

TP

CK increased

the level of TP decreased at eighth weeks in the model group (P<0.05

P<0.01). Compared with model group

the levels of ALT

AST

γ-GT

ALB

TP

CK decreased

the level of TP increased at eighth weeks in the Baoxin pill groups (P<0.05

P<0.01). Moreover

the alleviated pathological changes in heart tissues were observed in the Baoxin pill groups. Conclusion: Baoxin pill has a certain protective effect on liver function in rabbits with dilated cardiomyopathy induced by adriamycin.