Objective: The aim of this study was to evaluate the safety and efficacy of Huoxue Huayu method of Chinese herbal medicine in the treatment of ulcerative colitis(UC). Method: All the randomized controlled trials (RCTs) on activating blood circulation to remove blood stasis method of Chinese herbal medicine in the treatment of UC before June 2014 were searched in the CNKI

VIP

CBM and Wangfang database. The quality of RCTs meeting inclusion criteria was assessed and the related data were extracted;Meta-analysis was performed by Stata12.0 software. Result: Totally

20 RCTs involving 1 897 patients were included. Meta-analysis showed high effective rate [the total effective rate RR=1.248

95%CI(1.187

1.313)

Z=8.66

P<0.01] and safety. Sensitivity analysis showed that the evaluation result was stable. Funnel plot

Egger's test and Begg's test suggested no evidence of substantial publication bias. Conclusion: Huoxue Huayu method is more effective in the treatment of UC than the western medicine with higher safety. Because of the low quality of the included RCTs

the improvement of clinical research on the disease in high quality need to be confirmed.