Drug nature of Coptidis Rhizoma was reviewed in the paper which provided a new idea for research on drug nature.It is difficult to find a suitable research subject for discussing nature of Coptidis Rhizomaalthough some subjects were adopted in many researches. Some studies demonstrated that Coptidis Rhizoma

in a way

was a cold-natured medicine. However

it is still a long way to establish a criterion of cold-natured medicine. The emergency of interdiscipline may open a new door for exploring drug nature of Coptidis Rhizoma in the future. Epigenetic modifications

such as DNA methylation/demethylation

chromatin remodeling and histone modification

often change along with both inner and outer environment. Coptidis Rhizoma as an outer environmental factor may reversely regulate epigenetic modifications which are caused by diseases. Therefore

epigenetics may provide a new field in researches of drug nature ofCoptidis Rhizoma in the future.