冬凌草对血浆复钙作用的凝血活性成分

李高申; 郭梅珍; 张伟; 单远

doi:10.13422/j.cnki.syfjx.2015130059

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冬凌草对血浆复钙作用的凝血活性成分

化学与分析 | 更新时间：2024-01-04

- 冬凌草对血浆复钙作用的凝血活性成分
- Effect of Coagulant Active Constituents of Rabdosiae Rubescontis Herba on Plasma Recalcification Time
- 中国实验方剂学杂志 2015年21卷第13期页码：59-61
- 作者机构：
- 作者简介：
- 基金信息：
  
  河南省科技攻关重点项目(122102310647)
- DOI：10.13422/j.cnki.syfjx.2015130059
  中图分类号： R284
- 纸质出版日期：2015
- 稿件说明：
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李高申, 郭梅珍, 张伟, 等. 冬凌草对血浆复钙作用的凝血活性成分[J]. 中国实验方剂学杂志, 2015,21(13):59-61.

LI Gao-shen, GUO Mei-zhen, ZHANG Wei, et al. Effect of Coagulant Active Constituents of Rabdosiae Rubescontis Herba on Plasma Recalcification Time[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(13): 59-61.
李高申, 郭梅珍, 张伟, 等. 冬凌草对血浆复钙作用的凝血活性成分[J]. 中国实验方剂学杂志, 2015,21(13):59-61. DOI： 10.13422/j.cnki.syfjx.2015130059.

LI Gao-shen, GUO Mei-zhen, ZHANG Wei, et al. Effect of Coagulant Active Constituents of Rabdosiae Rubescontis Herba on Plasma Recalcification Time[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(13): 59-61. DOI： 10.13422/j.cnki.syfjx.2015130059.

摘要

目的: 从冬凌草中寻找具有血浆复钙作用的活性成分。方法: 对冬凌草乙酸乙酯部位和甲醇部位采用各种柱色谱进行分离纯化

以对体外血浆复钙时间的影响为活性指标

对冬凌草中活性成分进行筛选。结果: 从乙酸乙酯部位和甲醇部位共分离鉴定了6个化合物

其中

与维生素K1组相比

冬凌草甲素(1)和迷迭香酸(2)对血浆复钙时间的影响无显著性差异;与空白组相比

咖啡酸(3)对血浆复钙时间的影响无显著性差异;水杨酸(4)(214.77±5.8) s和阿魏酸(5)(233.43±6.88) s对血浆复钙时间小于空白组(252.23±2.6) s

大于维生素K1组(158.2±2.33) s;香草酸(6)(286.2±4.53) s对血浆复钙时间大于空白组

小于灯盏花素组(309.87±2.34) s。结论: 冬凌草甲素、迷迭香酸、水杨酸和阿魏酸具有促凝血作用;香草酸具有抗凝血作用。

Abstract

Objective: To obtain the active compounds of Rabdosiae Rubescontis Herba on plasma recalcification time. Method: EtOAC and methanol extracts were separated and purified by several kinds of chromatography

obserivedthe plasma recalcification time in vitro to screen theactive compounds of Rabdosiae Rubescontis Herba. Result: Six compounds were isolated and identified from the two extracts above. Compared with vitamin K1 group

oridonin (1) and rosmarinic acid (2) had no significant difference on plasma recalcification time(P>0.05). Compared with control group(200.87±2.45) s

caffeic acid (3) had no significant difference (P>0.05). The plasma recalcification times of salicylic acid (4)(214.77±5.8) s andferulic acid (5)(233.43±6.88) s were higherthan that of the control group (252.23±2.6) s

and lower than that of vitamin K1 group(158.2±2.33) s.The plasma recalcification time of vanillic acid (6)(286.2±4.53) s was longer than that of thecontrol group (252.23±2.6) s

and lower than that of breviscapine group (309.87±2.34) s. Conclusion: Oridonin

rosmarinic acid

salicylic acid andferulic acid had procoagulant activity

vanillic acid had anticoagulant effect.

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