“调肝肾,祛痰瘀”复方血压峰值前给药对自发性高血压大鼠心肾组织形态学的影响

吴椋冰; 潘毅; 王志国; 阳涛; 钟婷

doi:10.13422/j.cnki.syfjx.2015140082

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“调肝肾,祛痰瘀”复方血压峰值前给药对自发性高血压大鼠心肾组织形态学的影响

“调肝肾,祛痰瘀”复方研究专栏 | 更新时间：2024-01-04

- “调肝肾,祛痰瘀”复方血压峰值前给药对自发性高血压大鼠心肾组织形态学的影响
- Effect of Tiaoganshen Qutanyu-formula on Histomorphology of Heart and Kidney Tissue on Early Stage of Spontaneous Hypertensive Rats
- 中国实验方剂学杂志 2015年21卷第14期页码：82-86
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(81173181)
- DOI：10.13422/j.cnki.syfjx.2015140082
  中图分类号： R285.5
- 纸质出版日期：2015
- 稿件说明：
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吴椋冰, 潘毅, 王志国, 等. “调肝肾,祛痰瘀”复方血压峰值前给药对自发性高血压大鼠心肾组织形态学的影响[J]. 中国实验方剂学杂志, 2015,21(14):82-86.

WU Liang-bing, PAN Yi, WANG Zhi-guo, et al. Effect of Tiaoganshen Qutanyu-formula on Histomorphology of Heart and Kidney Tissue on Early Stage of Spontaneous Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(14): 82-86.
吴椋冰, 潘毅, 王志国, 等. “调肝肾,祛痰瘀”复方血压峰值前给药对自发性高血压大鼠心肾组织形态学的影响[J]. 中国实验方剂学杂志, 2015,21(14):82-86. DOI： 10.13422/j.cnki.syfjx.2015140082.

WU Liang-bing, PAN Yi, WANG Zhi-guo, et al. Effect of Tiaoganshen Qutanyu-formula on Histomorphology of Heart and Kidney Tissue on Early Stage of Spontaneous Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(14): 82-86. DOI： 10.13422/j.cnki.syfjx.2015140082.

摘要

目的: 探讨“调肝肾

祛痰瘀”复方血压峰值前给药对自发性高血压大鼠(SHR)早期心肾损害组织形态学的影响。方法: 将30只SHR(12周龄)

随机分为复方组(4 g ·kg-1)

氯沙坦组(30 mg ·kg-1)和模型组

另设SD大鼠10只为正常组

治疗12周后观察肾脏和心脏的超微结构和血管紧张素Ⅱ(AngⅡ)蛋白表达。结果: 与正常组比较

模型组肾小球系膜细胞核大

胞浆少

周围基膜明显增厚

胶原纤维增生明显

心肌细胞核

核形不规则

在核旁有些空染的区域

肌原纤维溶解消失

周围的线粒体发生了明显的空泡变性

大鼠肾组织和左心室组织AngⅡ的蛋白表达显著升高(P<0.01);与模型组比较

复方组和氯沙坦组均能明显改善SHR的心脏和肾脏超微结构

显著降低AngⅡ在肾脏和心脏的表达(P<0.01)。结论: 调肝肾

祛痰瘀”复方血压峰值前给药能够减轻高血压心肾损害病理损伤

其作用可能是在中医阴阳升降机制协同下

通过下调AngⅡ表达

减少细胞外基质(ECM)在心肾组织局部的聚集而实现。

Abstract

Objective: To observe the effect of Tiaoganshen Qutanyu-formula (TQF) on histomorphology of kidney tissue injury index on the early stage of spontaneous hypertensive rats (SHR) administered before blood pressure peak. Method: A total of 30 12-week male SHR were randomly divided into 3 groups:the TQF group (4 g · kg-1)

the losartan group (30 mg · kg-1) and the model group. Another healthy 10 SD rats were taken as the normal group. The kidney and heart ultrastructure and protein expression of angiotensin Ⅱ were observed after 12 weeks of treatment. Result: Compared with the normal group

the kidney and heart ultrastructure had varying degrees of injuries

the protein expression of angiotensin Ⅱ increased in the model group (P<0.01). Compared with the model group

the kidney and heart ultrastructure had good improvement

the protein expression of angiotensin Ⅱ decreased in the TQF group (P<0.01). Conclusion: TQF taken before blood pressure peak could reduce the pathological injury of kidney and heart. The mechanism might be the synergistic effect of Yin-yang theory of preventing the aggregation of extra cellular matrix by reducing the expression of angiotensin Ⅱ.

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