Objective: Explore the Clinical efficacy of combined Soothing liver and Kidney decoction with Clomiphene in the treatment of anovulatory infertility and theeffect of sex hormonesetc. Method: Ninety cases of anovulalory infertility were divided into treatment group and control group by using random number method. The treatment group received the treatment of Shugan Yishen recipe combined with clomiphene;the control group was treated with clomiphene treatment only. The period of the two groups was 3 menstrual cycles. Use B-ultrasonic wave to monitor the development of ovarian follicles

count the ovulation rate

pregnancy rate and miscarriage rate. Enzyme-linked immuno sorbent assay (ELISA) measured the levels of testosterone (T)

prolactin (PRL)

estradiol (E2)

luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Result: The ovulation rate and pregnancy rate of treatment group were higher than control group

while abnormal menstruation cases and miscarriage rate were lower than control group after treatment. Endometrial thickness were significantly improved in the treatment group. The levels of LH

FSH

T and PRL in treatment group were lower than control group'. Two estradiol levels were reduced

there were no significant difference between the groups. Conclusion: Shugan Yishen recipe can responsiveness of the penis in kidney

regulate the liver and the menstrual function to increase the pregnancy rate and it was better than clomipheneclinically.