Objective: To investigate the effect of Dantian Jingshu capsule onhemorheology of vertebral artery type cervical spondylosis (CSA) model rabbits. Method: Seventy rabbits were randomly divided into 7 groups:normal group

model group

Dantian Jingshu capsule group(0.36

0.72

1.44 g · kg-1)

positive control group(Jing Fukang granules 1.0 g · kg-1 and flunarizine 0.001 g · kg-1). Rabbits were injected with 775 injection(tissue sclerosing agent) in the left side of cervical vertebrae to make animal model of CSA. To observe the effects of Dantian Jingshu capsule on hemorheology[whole blood viscosity

plasma viscosity

whole blood viscosity reduction

hematocrit(HCT)

erythroeyte aggregation index(EAI)

red cell rigidity index(ERI)

red cell deformation index (EDI)and fibrinogen] of the rabbits by intragastric administration after two weeks. Result: Compared with normal group

the hemorheology index of model group (blood viscosity

plasma viscosity

HCT

whole blood viscosity reduction

EAI) were obviously decrease. So there was significant differences between normal group and model group(P <0.01). Compared with model group

blood viscosity and aggregation of red-cells were obviously decrease and erythrocyte deformability was increased in Dantian Jingshu capsule group(P <0.01). Conclusion: Dantian Jingshu capsule could reduce the CSA model rabbits erythrocyte aggregation and reinforce the ability of erythocyte deformability so that improve its blood viscosity. Dantian Jingshu capsule can improve the CSA model rabbits' symptom of cerebral ischaemia.