Objective: To observe the efficacy of Kangxian'gan decoction in treating liver fibrosis caused by chronic hepatitis B and its effect on serum leptin and transforming growth factor-β1(TGF-β1). Method: Totally 106 patients were divided into the control group (54 cases) and the observation group (52 cases) by the random number table. Both groups received Adefovir Dipivoxil tablets

10 mg/time

1 time/day. Patients in the control group took Fuzheng Huayu capsules

1.5 g/time

3 times/day. Patients in the observation group took Kangxiangan decoction

1 dose/day. The treatment courses of both groups lasted for 48 weeks. The hyaluronic acid (HA)

laminin (LN)

serum levels of procollagen type III (PCIII)

serum level of collagen type IV (IV-C)

aspartate aminotransferase (AST)

alanine aminotransferase (ALT)

total bilirubin (TBIL)

albumin (ALB)

HBV-DNA

TGF-β1and leptin levels were detected. The HBV serological markers (HBV-M) were detected by the euzymelinked immunosorbent assay before and after the treatment. The portal vein diameter

splenic vein diameter

thickness of spleen and blood flow velocity were detected by the color Doppler ultrasound. Result: According to the Ridit analysis

the clinical efficacy in the observation group was higher than that in the control group (P< 0.05). After the treatment

the serum HA

PCⅢ

LN and IV-C levels in the observation group were less than that in the control group (P< 0.01). After the treatment

ALT

AST and TBIL levels in the observation group were lower than that in the control group (P< 0.01)

but with higher ALB level than the control group (P< 0.01). The HBeAg negative conversion rate in the observation group was 29.6%

while that in the control group was 25%

with no statistical significance in their difference. The HBV-DNA

leptin and TGF-β1 levels in the observation group were lower than that in the control group after the treatment (P< 0.01). The portal vein diameter

spleen vein diameter

thickness of spleen in the observation group were lower than that in the control group

but with faster blood flow velocity than the control group (P< 0.01). Conclusion: In addition to the antiviral treatment

Kangxian'gan decoction can resist viruses

protect the liver function

improve the color doppler ultrasound of liver and spleen

reduce serum leptin and TGF-beta 1 levels. It has the inhibitory effect on the development of liver fibrosis caused by Chronic hepatitis B

with a better clinical efficacy than Fuzheng Huayu capsules.