Objective: To assess the efficacy of the integrated traditional Chinese medicine and western medicine for Treatment of hyperthyroidism using systematic review. Method: Randomized controlled trialsonthe integrated traditional Chinese medicine and western medicine as well as western medicine alone for treatment of hyperthyroidism were searched in electronic databases;all relevant literatures were screened according to inclusion criteria and data was extracted

then analyzed with Stata10.1 software. Result: The 21 randomized controlled trials met the inclusion criteria

including 1 394 patients. Compared with western medicine alone

the integrated traditional Chinese medicine and western medicine significantly improved clinical effect [OR=3.26

95%CI (2.30

4.64)

P<0.01]

and the integrated traditional Chinese medicine and western medicine had significantly better effects than western medicine alone in improving free triiodothyronine(FT3)

free thyroxine (FT4)

thyroid-stimulating hormone (TSH)

thyroid microsomal antibody(TMA)

and thyroglobulin antibody(TGA)

but there was no difference in thyromegaly improvement between two groups. Conclusion: The integrated traditional Chinese medicine and western medicine has significantly better effects than western medicine alone in treatment of hyperthyroidism

especially in improving FT3

FT4

TSH

TMA and TGA levels.