Objective: To investigate the medication rules of traditional Chinese medicines(TCM) for the treatment of hepatopathy by National Medical Masters. Method: The prescriptions for hepatopathy were collected to build a database based on TCM inheritance assist system. Apriori algorithm and complex system entropy cluster were adopted to determined the frequency of single medicine and drug combinations that used in prescriptions

and the association rules between drugs e. Result: Frequently used herbs included Poria

Salviae Miltiorrhizae Radix et Rhizoma

Artemisiae Scopariae Herba

Atractylodis Macrocephalae Rhizoma and Bupleuri Radix;Frequently used drug combinations included 'Salviae Miltiorrhizae Radix et Rhizoma and Poria'

'Atractylodis Macrocephalae Rhizoma and Poria' and 'Salviae Miltiorrhizae Radix et Rhizoma and and Paeoniae Radix Rubra'.The association rules with a confidence of above 0.6 included 'Astragali Radix-> Salviae Miltiorrhizae Radix et Rhizoma and'

'Atractylodis Macrocephalae Rhizoma-> Poria'

'Astragali Radix-> Poria' and 'Pilosula Codonopsis-> Poria'. Conclusion: The prescriptions used for the treatment of hepatopathy mostly have the effects of reinforcing spleen and eliminating dampness

cooling blood and activating blood circulation

nourishing Yin to calm liver and discharging liver and relieving depression

with the refined compatibility and the TCM medication principles for treating symptoms and root causes.