Objective: To systemically assess the efficacy of the integrated traditional Chinese medicine(TCM) and western medicine for treatment of hashimoto's hypothyroidism. Method: The randomized controlled trials (RCTs) of the integrated TCM and western medicine as well as western medicine alone for treatment of Hashimoto's hypothyroidism were searched by electronic databases. All relevant literature were selected according to the inclusion criteria and data was extracted

then Stata10.1 software was used for statistic analysis. Result: The 13 randomized controlled trials were included in the study

with 1 017 patients in total. Compared with western medicine alone group

the observation group of integrated TCM and western medicine significantly improved the clinical efficacy[OR=3.89

95%CI (2.71

5.59)

P<0.01]. In terms of TPOAb and TGAb

the observation group was significantly superior to western medicine alone group[SMD=-1.62

95%CI(-2.29

-0.95)

P<0.01;SMD=-2.96

95%CI(-3.92

-1.99)

P<0.01

respectively). Conclusion: The integrated TCM and western medicine is obviously superior to western medicine alone for treatment of Hashimoto's hypothyroidism

especially in improving TGAb and TPOAb.