Objective: To investigate effects of Qiwei Baizhu San

Qiwei Baizhu drops and Qiwei Baizhu extract on diarrhea

intestinal pathological damage and tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in serum of mice with intestinal flora. Method: Ceftriaxone

lincomycin hydrochloride and iced senna were gavaged to mice to induce the intestinal flora model. The mice were divided into 5 groups:normal group

model group (natural recovery group after successfully modeling)

Qiwei Baizhu San group

Qiwei Baizhu drops group and Qiwei Baizhu extract group. Analysis was made for diarrhea

small intestinal epithelial histopathology and the content of TNF-α and IL-6 in serum after treatment. Result: Compared with the normal group

the quantity of Enterococci

Escherichia coli

Lactobacillus and Bifidobacterium bacteria in the model group increased significantly (P<0.05

P<0.01)

indicating the successful modeling. Different formulated Qiwei Baizhu San can reduce the number of diarrhea in animal models

lower degree of diarrhea

the rate of diarrhea and diarrhea index

relieve the small intestinal pathological damage and reduce the level of TNF-α and IL-6 in serum. But the decoction group showed a lower effect than the drop group and the extract group. Conclusion: Qiwei Baizhu San can correct diarrhea of mice with intestinal flora

and its mechanism may be correlated with promotion of the injured intestinal mucosa injury and repair and reduction of the release of inflammatory cytokines.