Objective: To compare the chemotherapy combined with Sijunzi Tang and chemotherapy alone in clinical efficacy

quality of life

and side effects in treatment of colorectal cancer. Method: We searched for the literature of randomized controlled trials

published before October 2015 in both Chinese and English

comparing the chemotherapy combined with Sijunzi Tang and chemotherapy alone in clinical efficacy

quality of life

and side effects in treatment of colorectal cancer. Software Review Manager 5.3 was used to evaluate the quality of the included literature and conduct statistics work. Result: After strict screening

the 8 literature of randomized controlled trials were selected finally

involving 483 patients

the 245 cases with chemotherapy combined with Sijunzi Tang and 238 cases with chemotherapy alone. Results of Meta-analysis showed that there were statistically significant differences between two group in the quality of life and side effects (P<0.000 01). There was no significant difference in clinical efficacy (P=0.19). Conclusion: Sijunzi Tang can not only decrease the incidence of side effects of chemotherapy in patients with colorectal cancer

but also improve the quality of life for the patients.