Objective: To study the fingerprints of Pien Tze Huang by total quantum statistical moment (TQSM) and total quantum statistical moment similarity (TQSMS) method

further verify the relevance between the previously established methods

and provide basis for the quality control of Pien Tze Huang. Method: With Notoginsenoside R1

ginsenoside Rg1

ginsenoside Rb1and sodium taurocholic acid as the control products

RP-HPLC was used to establish the chromatographic fingerprints of Pien Tze Huang

and the correlation between TQSM and TQSMS of the fingerprints was analyzed. Result: There were 14 common characteristic peaks for 10 batches of Pien Tze Huang samples. By using TQSM method

the average values of AUCT

relative AUCT

λT

relativeλT

σT

relative σTwere calculated as 7.430×106 μV·sec

1.002

22.540 min

0.972

5.391 min

1.065 and their RSD were 5.0%

4.3%

1.0%

1.0%

2.9%

2.9% respectively. The average similarity was 0.943 and RSD was 1.9% compared with reference fingerprint by TQSMS. The correlation coefficient of relative λTand similarity was 0.980

P<0.01

and the correlation coefficient of relative σTand similarity was -0.683

P<0.05

with statistically significant difference. Conclusion: There was correlation between TQSM and TQSMS and this method was additive

couplable and statistical. Besides

the established chromatographic fingerprint was highly precise and reproducible

thus can be applied in the quality control of Pien Tze Huang.