Recurrent oral ulcer (ROU) is a common disease of oral mucosa

with a high incidence rate and complicated etiology. It is correlated with many factors

such as abnormal immune function

oral flora disorder

infection

microcirculation disturbance

trace element deficiency and endocrine disorders

but the exact cause and pathogenesis are still unknown. The imbalance of oral micro-ecosystem and immune system is a hotspot in current studies. Oral microbial imbalance has been paid more and more attention by domestic and foreign scholars

and the studies on oral bacteria have some progress. However

viral genome

which is the most abundant member of oral microbial community

has not been further studied. With the great advantages of virus macro genomics in the medical field

high throughput sequencing method has been rapidly promoted in the field of viral genomics studies

and grown into a powerful tool for solving virus-host interactions. According to traditional Chinese medicine (TCM)

ROU is also known as recurrent aphthous

whose etiology and pathogenesis are dominated by 'inflammation'. The inflammatory syndromes in spleen and stomach are the most common

which is closely related to the imbalance of oral micro-ecosystem and immune disorders. Study on micro ecological regulation

as an advantageous field of TCM

starts with oral viral genome and TCM's therapeutic mechanism for ROU

and focuses on core molecular mechanisms of ROU through high throughput sequencing method. It is expected to observe dynamically oral viral genomes regulation mode of TCM compounds

and reveal TCM's micro-ecological connotation reaching clinical curative effect. It is of important significance to fully understand the ROU pathogenesis

and give better guidance to clinical treatment.