Objective: To study the constituents of the high polar fraction of the leaves of Artocarpus heterophyllus

determine the antihyperlipidemia effective products in of the high polar fraction except polysaccharides

and provide a scientific basis for their subsequentant research and utilization. Method: The 10 kg rough power of the leaves of A. heterophyllu was extracted with 60%ethanol twice. The extract was combined and concentrated under reduced pressure at 4℃

standed for 24 h and filtered. The filtrate was concentrated as the high polar fraction. The high polar fraction was isolated with macroporous resin and sephadex column chromatography

and preparative HPLC. The obtained monomeric compounds were identificated by UV

MS

H-NMR and C-NMR. Result: Three compounds were separated and purified from the high polar fraction of the leaves of A. heterophyllus

and identified as vitexin-2″-O-xylosiden (compound 1， 80.5 mg)

a flavone C-glycoside with two monosaccharides

molecular formula C26H28O14

relative molecular mass 564; isoquercitrin (compound 2， 4.8 mg)

molecular formula C21H20O12

relative molecular mass 464; samsesquinoside (compound 3， 12.6 mg)

a lignin grape glycoside with one monosaccharide

molecular formula C37H46O16

relative molecular mass 746. Conclusion: Compound 1 and 3 are discovered from A.heterophyllus for the first time. Our previous research work showed that the high polar fraction except polysaccharides had favorable hypolipidemic activity. The content of vitexin-2″-O-xylosiden in the high polar fraction of A.heterophyllus is relatively high and is the one of the antihyperlipidemia effective constituents probably.