单因素配伍剂量对大黄甘草汤药效组分的影响

武亚楠; 张贵君; 刘亮; 彭慧; 向丽; 杨颜芳; 许洪亮

doi:10.13422/j.cnki.syfjx.2016160084

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单因素配伍剂量对大黄甘草汤药效组分的影响

药物代谢 | 更新时间：2024-01-04

- 单因素配伍剂量对大黄甘草汤药效组分的影响
- Influence of Single Factor Compatible Dose on Active Components in Dahuang Gancao Tang
- 中国实验方剂学杂志 2016年22卷第16期页码：84-90
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2016160084
  中图分类号： R284.1
- 纸质出版日期：2016
- 稿件说明：
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武亚楠, 张贵君, 刘亮, 等. 单因素配伍剂量对大黄甘草汤药效组分的影响[J]. 中国实验方剂学杂志, 2016,22(16):84-90.

WU Ya-nan, ZHANG Gui-jun, LIU Liang, et al. Influence of Single Factor Compatible Dose on Active Components in Dahuang Gancao Tang[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(16): 84-90.
武亚楠, 张贵君, 刘亮, 等. 单因素配伍剂量对大黄甘草汤药效组分的影响[J]. 中国实验方剂学杂志, 2016,22(16):84-90. DOI： 10.13422/j.cnki.syfjx.2016160084.

WU Ya-nan, ZHANG Gui-jun, LIU Liang, et al. Influence of Single Factor Compatible Dose on Active Components in Dahuang Gancao Tang[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(16): 84-90. DOI： 10.13422/j.cnki.syfjx.2016160084.

摘要

目的：研究大黄甘草汤中配伍饮片生大黄或生甘草剂量改变对该复方药效组分的影响，为该复方的临床合理应用和中药药效组分质量评价体系建立提供参考。方法：采用HPLC-DAD同时测定不同配伍的大黄甘草汤中通便止呕的药效组分芦荟大黄素-甘草酸-大黄酸-大黄素-大黄酚-大黄素甲醚（波长254 nm），甘草苷-甘草素（波长276 nm），番泻苷B-番泻苷A-异甘草苷-异甘草素（波长360 nm）的含量。结果：大黄甘草汤中生大黄（或生甘草）配伍剂量增加时，生甘草（或生大黄）药效组分均逐渐降低。当大黄与甘草配伍剂量为经方比例12 g/3 g时，甘草苷、异甘草苷、甘草素、异甘草素和甘草酸的质量分数依次为（1258.03±35.52），（115.26±7.88），（246.09±4.02），（15.41±0.20），（1823.44±23.44）μg·g-1；番泻苷B，番泻苷A，芦荟大黄素，大黄酸，大黄素，大黄酚和大黄素甲醚质量分数依次为（124.51±0.60），（189.91±7.04），（214.03±6.08），（1110.60±24.36），（193.83±0.95），（133.21±3.28），（51.26±1.00）μg·g-1。结论：配伍剂量改变时，大黄甘草汤药效组分的溶出量与经方比较均具有显著性差异，说明其功效随配伍剂量的不同而变化。生大黄（生甘草）的配伍剂量改变对甘草（大黄）、其自身及大黄甘草汤药效组分总量均有显著影响。生甘草配伍剂量对大黄甘草汤药效组分的影响强于生大黄。

Abstract

Objective: To investigate the influence of dose change of Rhei Radix et Rhizoma and Glycyrrhizae Radix et Rhizoma on active components alignment in Dahuang Gancao Tang by using single factor analysis

to provide scientific basis for clinical rational use of this prescription and establishing the quality standard of traditional Chinese medicine. Method: HPLC-DAD was employed to determine the content of aloeemodin-rhein-glycyrrhizic acid-emodin-chrysophanol-physcion (λ=254 nm)

liquiritin-liquiritigenin (λ=276 nm)

sennoside B-sennoside A-isoliquiritin-isoliquiritigenin (λ=360 nm) in Dahuang Gancao Tang with different compatibility of herbs. Result: When compatible dose of Glycyrrhizae Radix et Rhizoma or Rhei Radix et Rhizoma in Dahuang Gancao Tang increased

contents of active components in Rhei Radix et Rhizoma or Glycyrrhizae Radix et Rhizoma reduced without exception.When compatible dose of Rhei Radix et Rhizoma-Glycyrrhizae Radix et Rhizoma stayed 12 g/3 g

contents of liquiritin-isoliquiritin-liquiritigenin-isoliquiritigenin-glycyrrhizic acid were (1 258.03±35.52)

(115.26±7.88)

(246.09±4.02)

(15.41±0.20)

(1 823.44±23.44) μg·g-1;contents of sennoside B-sennoside A-aloeemodin-rhein-glycyrrhizic acid-emodin-chrysophano1-physcion were (124.51±0.60)

(189.91±7.04)

(214.03±6.08)

(1 110.60±24.36)

(193.83±0.95)

(133.21±3.28)

(51.26±1.00) μg·g-1. Conclusion: As compatible dose of Rhei Radix et Rhizoma and Glycyrrhizae Radix et Rhizoma dose changing

dissolution of active components alignment in Dahuang Gancao Tang is significantly different by comparing with classic compatibility

efficacy of Dahuang Gancao Tang changes with compatible dose.Changes of compatible dose of Rhei Radix et Rhizoma (Glycyrrhizae Radix et Rhizoma) have significant influence on active components alignment in Glycyrrhizae Radix et Rhizoma (Rhei Radix et Rhizoma)

itself and Dahuang Gancao Tang.Influence of dose of Glycyrrhizae Radix et Rhizoma on active components alignment in Dahuang Gancao Tang is stronger than that of Rhei Radix et Rhizoma.

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