Objective: To mine data and analyze the clinical cases of Professor XIA Xiang

in order to disclose his formula rules in treating cardiovascular and cerebrovascular diseases with Qi-supplementing and blood-activating method

and suggest methods and herbs for this disease. Method: The first-visit cardiovascular and cerebrovascular cases treated by Pro. XIA Xiang with Qi-supplementing and blood-activating method were collected

and the selected cases were entered in the Traditional Chinese Medicine Inheritance Support Platform (V2.5

TCMISS) to analyze the rules of Qi-supplementing and blood-activating method

herbs and symptoms through data mining. Then two disease entities with the largest number of cases were selected to further analyze the association rules of diseases

therapies and herbs. Result: Totally 89 formulas were collected

including 28 cases of headache and palpitation

17 cases of chest distress

15 cases of vertigo and 1 case of stroke. The common symptoms in order were fluster

chest distress

headache

dizzy

chest pain

insomnia

chill

fatigue

thirst

alliteration and tinnitus. They involved totally 220 types of herbs in 89 formulas

which were dominated by Qi-supplementing and blood-activating herbs

such as Astragali Radix

Salviae Miltiorrhizae Radix et Rhizoma

Puerariae Lobatae Radix

Codonopsis Radix and Chuanxiong Rhizoma. There were 8 and 15 common herbs treating headache and palpitation with the support score ≥18 and 15

involving 21 and 25 herbal pairs

there were 32 and 15 herbal combinations with the confidence score ≥95%

which produced 8 and 9 new formulas

respectively. Conclusion: TCMISS disclosed Pro. XIA Xiang's formulas rules for treating the cardiovascular and cerebrovascular diseases with the Qi-supplementing and blood-activating method

which helps promote the clinical efficacy of TCM.