Objective: To study the changes of three lactone components of Andrographis Herba during the production process of Chuanwang Xiaoyan capsules

and select the reasonable components as the detection indexes to strengthen the quality control. Method: The production process of Chuanwang Xiaoyan capsules was tracked

and the key process points were selected as monitoring points. Quality was monitored by using HPLC. The dynamic content changes of andrographolide

neoandrographolide and didehydroandrographolide were tracked; the losses amount was calculated and relative change trend of transfer rate was compared. Result: The losses amount of andrographolide

neoandrographolide and didehydroandrographolide in the whole production process was different

and it was also greatly different during different process stages. The losses amount was 410.65-619.79 mg for andrographolide

375.97-381.12 mg for neoandrographolide

and 147.52-261.04 mg for didehydroandrographolide. Conclusion: By exploring the changes regularity of the three andrographolide contents in the process

it provides a reference for relevant enterprises to establish reasonable detection indexes. It lays a foundation for improving the quality controllability of the formulation containing Andrographis Herba

with more practical reference values.