Objective: To evaluate the effect of Shashen Maidong Tang combined with chemotherapy on the immune function and inflammatory reaction of patients with lung cancer of Qi and Yin deficiency

and investigate its mechanism of action. Method: The 110 patients with non small cell lung cancer in Zunyi Hospital of Traditional Chinese Medicine were randomly divided into treatment group and control group

55 cases in each group. Both groups of patients were given with corresponding treatment measures. The patients in control group were treated with chemotherapy of gemcitabine+cisplatin

and the patients in treatment group were treated with Shashen Maidong Tang on the basis of the treatment in control group

200 mL/time

1 dose/d

one time in the morning and one time in the evening. 21 days were regarded as one treatment course

and they were treated for two consecutive courses in both groups. Serum CD4+

CD8+

CD4+/CD8+

natural killer cell (NK)

interleukin-6 (IL-6)

tumor necrosis factor-α (TNF-α)

effective rate

Kamofsky patients health status score (KPS)

body mass change and adverse reaction incidence were observed and compared before and after treatment in two groups. Result: As compared with the conditions before treatment

CD8+

IL-6

and TNF-α levels were decreased

and the level of CD4+

CD4+/CD8+ were increased in both groups after treatment (P <0.05). After treatment

the CD8+

IL-6

TNF-α levels were lower

while CD4+

CD4+/CD8+ levels were higher in treatment group than those in control group (P <0.05); and there was no significant difference in the level of NK cells between two groups before and after treatment. After treatment

the effective rate of clinical treatment

KPS score and body mass stable rate were higher

and incidence of adverse reactions was lower in treatment group as compared with those in control group (P <0.05). Conclusion: Shashen Maidong Tang combined with chemotherapy can improve the immune function of patients with Qi and Yin deficiency type lung cancer

and reduce the inflammatory reaction in patients

with higher clinical efficacy and safety.