不同方法炮制的熟地黄的补血作用比较

赵丹; 张振凌; 王胜超; 王光会; 于文娜; 夏云岭

doi:10.13422/j.cnki.syfjx.2017190046

您当前的位置：

首页 >

文章列表页 >

不同方法炮制的熟地黄的补血作用比较

药剂与炮制 | 更新时间：2024-01-04

- 不同方法炮制的熟地黄的补血作用比较
- Comparison of Enriching Blood Effect of Rehmanniae Radix Praeparata Processed by Different Methods
- 中国实验方剂学杂志 2017年23卷第19期页码：46-49
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家中医药行业科研专项（201507002）;河南中医药大学创新基金项目（2015YCX019）
- DOI：10.13422/j.cnki.syfjx.2017190046
  中图分类号： R283.3
- 纸质出版日期：2017
- 稿件说明：
移动端阅览
赵丹, 张振凌, 王胜超, 等. 不同方法炮制的熟地黄的补血作用比较[J]. 中国实验方剂学杂志, 2017,23(19):46-49.

ZHAO Dan, ZHANG Zhen-ling, WANG Sheng-chao, et al. Comparison of Enriching Blood Effect of Rehmanniae Radix Praeparata Processed by Different Methods[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(19): 46-49.
赵丹, 张振凌, 王胜超, 等. 不同方法炮制的熟地黄的补血作用比较[J]. 中国实验方剂学杂志, 2017,23(19):46-49. DOI： 10.13422/j.cnki.syfjx.2017190046.

ZHAO Dan, ZHANG Zhen-ling, WANG Sheng-chao, et al. Comparison of Enriching Blood Effect of Rehmanniae Radix Praeparata Processed by Different Methods[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(19): 46-49. DOI： 10.13422/j.cnki.syfjx.2017190046.

摘要

目的：比较不同方法加工炮制的熟地黄饮片的补血作用。方法：采用环磷酰胺和盐酸苯肼结合法进行血虚模型的建立，分别设立空白组、模型组、阿胶补血口服液组、传统酒炖组和产地加工饮片炮制一体化组，每组给药体积均为0.02 mL · g-1，后三者的给药剂量分别为10 mL · kg-1，3.75，3.75 g · kg-1。以全血外周血象、脏器指数和血清中促红细胞生成素（EPO）含量为指标对不同方法加工的熟地黄的补血作用进行综合评价。结果：与模型组相比，各给药组红细胞数目均较显著性升高（P<0.01）；产地加工饮片炮制一体化组较显著性升高白细胞和血红蛋白（P<0.01），EPO（P<0.01）恢复至正常水平；传统酒炖组显著升高白细胞（P<0.05），EPO（P<0.05）恢复至正常水平；产地加工饮片炮制一体化组显著升高了胸腺指数（P<0.01），传统酒炖组明显升高了胸腺指数（P<0.05）。与空白组相比，模型组小鼠各指标均呈现显著性差异；与阿胶补血口服液组相比，产地加工饮片炮制一体化组明显升高了血红蛋白（P<0.05）；与传统酒炖组相比，产地加工饮片炮制一体化组血红蛋白较显著性升高（P<0.01）。结论：不同方法加工的熟地黄饮片均有一定的补血作用，产地加工饮片炮制一体化组的熟地黄饮片略优于传统酒炖组，且该加工工艺具有一定的可行性。

Abstract

Objective: To compare the different effect of Rehmanniae Radix Praeparata processed by different methods on the chemical damage anemia in mice as model of blood deficiency. Method: Blood deficiency model were induced by phenylhydrazine hydrochloride and cyclophosphamide.The experimental animals were randomly divided into blank group

model group

Ejiao blood enriching oral liquid group

traditional wine stewing group and origin processing integration group.The administration volume was 0.02 mL·g-1

and dose of the latter three was 10 mL·kg-1

3.75

3.75 g·kg-1

respectively.Enriching blood effect of Rehmanniae Radix Praeparata processed by different methods was evaluated by taking hemogram

level of erythropoietin(EPO) in serum and organ index as indexes. Result: Compared with the model group

red blood cells (RBC) of each administration group increased significantly (P<0.01);white blood cells (WBC) and hemoglobin (HB) of origin processing integration group increased significantly (P<0.01)

EPO was gradually restored to normal level and significantly decreased (P<0.01);WBC was increased in the traditional wine stewing group (P<0.05)

while EPO (P<0.05) returned to normal levels;Thymus index of origin processing integration group was significantly increased (P<0.01) and the parameter in traditional wine stewing group was increased (P<0.05).Compared with the blank group

these indexes of model group were significantly different.Compared with the Ejiao blood enriching oral liquid group

HB (P<0.05) was significantly increased in the origin processing integration group.Compared with the traditional wine stewing group

HB of the origin processing integration group was significantly increased (P<0.01). Conclusion: Rehmanniae Radix Preparata processed by different methods has a certain blood enriching effect.Among them

the origin processing integration group is better than the traditional wine stewing group.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

四物汤及其三味药组方对γ射线照射致血虚证小鼠造血系统的影响

基于QbD理念的煅赭石炮制工艺优化及健康风险评估

姜黄连的炮制历史沿革及现代研究进展

基于指纹图谱与含量测定的地骨皮与焙地骨皮质量评价

六味地黄丸定量分析方法和评价体系的建立