枳壳不同炮制品的燥性比较及其对功能性消化不良大鼠胃肠功能的影响

祝婧; 钟凌云; 叶喜德; 龚千锋; 张金莲

doi:10.13422/j.cnki.syfjx.2017220020

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枳壳不同炮制品的燥性比较及其对功能性消化不良大鼠胃肠功能的影响

药剂与炮制 | 更新时间：2024-01-04

- 枳壳不同炮制品的燥性比较及其对功能性消化不良大鼠胃肠功能的影响
- Comparison of Dryness in Different Processed Products of Aurantii Fructus and Investigation of Their Effect on Gastrointestinal Function in Rats with Functional Dyspepsia
- 中国实验方剂学杂志 2017年23卷第22期页码：20-26
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家中医药管理局公益性行业科研专项（201507002-2）。
- DOI：10.13422/j.cnki.syfjx.2017220020
  中图分类号： R283;R285.5
- 纸质出版日期：2017
- 稿件说明：
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祝婧, 钟凌云, 叶喜德, 等. 枳壳不同炮制品的燥性比较及其对功能性消化不良大鼠胃肠功能的影响[J]. 中国实验方剂学杂志, 2017,23(22):20-26.

ZHU Jing, ZHONG Ling-yun, YE Xi-de, et al. Comparison of Dryness in Different Processed Products of Aurantii Fructus and Investigation of Their Effect on Gastrointestinal Function in Rats with Functional Dyspepsia[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(22): 20-26.
祝婧, 钟凌云, 叶喜德, 等. 枳壳不同炮制品的燥性比较及其对功能性消化不良大鼠胃肠功能的影响[J]. 中国实验方剂学杂志, 2017,23(22):20-26. DOI： 10.13422/j.cnki.syfjx.2017220020.

ZHU Jing, ZHONG Ling-yun, YE Xi-de, et al. Comparison of Dryness in Different Processed Products of Aurantii Fructus and Investigation of Their Effect on Gastrointestinal Function in Rats with Functional Dyspepsia[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(22): 20-26. DOI： 10.13422/j.cnki.syfjx.2017220020.

摘要

目的：比较枳壳不同炮制品的燥性，考察其对功能性消化不良（FD）大鼠胃肠功能的影响。方法：以大鼠饮水量、排尿量、肾水通道蛋白3（AQP3）含量、血清环磷酸腺苷（cAMP）与血清环磷酸鸟苷（cGMP）比值为评价指标，观察不同剂量的枳壳生品、麸炒枳壳、蜜麸枳壳对健康大鼠水液代谢的影响；以胃黏膜损伤指数，血清肿瘤坏死因子-α（TNF-α），白细胞介素6（IL-6），IL-8含量为评价指标，观察不同剂量枳壳生品、麸炒枳壳、蜜麸枳壳对健康大鼠胃黏膜损伤的影响；以大鼠胃残留率和小肠推进率，血清胃动素（MTL），血管活性肠肽（VIP），降钙素基因相关肽（CGRP）含量为评价指标，观察不同剂量枳壳生品、麸炒枳壳、蜜麸枳壳对FD大鼠胃肠功能的影响。结果：在水液代谢方面，同等剂量给药组与空白组相比，差异性排序为枳壳生品 >麸炒枳壳 >蜜麸枳壳，且高剂量组>低剂量组；在胃黏膜损伤方面，不同剂量枳壳生品、麸炒枳壳、蜜麸枳壳组各项指标与空白组比较均无显著性差异；在促胃肠动力方面，同等剂量给药组与模型组相比，差异性为麸炒枳壳 >枳壳生品 >蜜麸枳壳，且低剂量组>高剂量组。结论：枳壳生品的燥性主要表现为对机体津液的损伤，且强度与剂量有关，对健康大鼠胃黏膜未见明显直接刺激。炮制后可在一定程度上缓和伤津之弊，且以蜜麸枳壳缓和作用最佳；枳壳生品和炮制品均可促进FD大鼠胃肠功能的恢复，麸炒枳壳治疗作用优于生品与蜜麸制品。

Abstract

Objective: To compare the dryness in different processed products of Aurantii Fructus

and investigate their effect on gastrointestinal function of functional dyspepsia(FD) rats. Method: Taking water intake

urinary output

aquaporin 3(AQP3) content in kidney and serum cyclic adenosine monophosphate(cAMP)/serum cyclic guanosine monophosphate(cGMP) as indexes

effect of crude and processed products of Aurantii Fructus with different doses on the water metabolism of healthy rats was observed.Taking gastric mucosal damage index and contents of serum tumor necrosis factor-α (TNF-α)

interleukin-6(IL-6)

IL-8 as indexes

effect of crude and processed products of Aurantii Fructus with different doses on gastric mucosal injury of healthy rats was observed.Taking gastric remnant rate

intestinal propulsive rate and contents of serum motilin(MTL)

vasoactive intestinal peptide(VIP)

calcitonin gene-related peptide(CGRP) as indexes

effect of crude and processed products of Aurantii Fructus with different doses on gastrointestinal function of functional dyspepsia rats was observed. Result: In the aspect of water metabolism

the same dose of medicine compared with the blank group

difference was in the order of Aurantii Fructus > Aurantii Fructus fried with bran > Aurantii Fructus fried with honey and bran

and the high dose group is higher than the low dose group.In indexes of gastric mucosal injury

there was no significant difference between processed products of Aurantii Fructus and the blank group.In the aspect of gastrointestinal motility

the same dose of medicine compared with the model group

difference was in the order of Aurantii Fructus fried with bran > Aurantii Fructus > Aurantii Fructus fried with honey and bran

and the low dose group > the high dose group. Conclusion: The dryness of Aurantii Fructus is mainly performance for body fluid injury

the degree is related to the drug dosage

and it has no obvious stimulation of stomach.After being processed

Aurantii Fructus can relax the body fluid injury to a certain extent

and Aurantii Fructus fried with honey and bran has the best effect to ease the adverse reaction.Different processed products of Aurantii Fructus all can promote the recovery of gastrointestinal function of FD rats

and the treatment of Aurantii Fructus fried with bran is stronger than the crude and honey-bran products.

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