复方血脂宁中4种药材对二苯乙烯苷稳定性的影响

李超; 任晓亮; 王萌; 孙立丽; 陈林

doi:10.13422/j.cnki.syfjx.2018020019

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复方血脂宁中4种药材对二苯乙烯苷稳定性的影响

药剂与炮制 | 更新时间：2024-01-04

- 复方血脂宁中4种药材对二苯乙烯苷稳定性的影响
- Effect of Four Medicinal Herbs on Stability of Stilbene Glucoside in Compound Xuezhining
- 中国实验方剂学杂志 2018年24卷第2期页码：19-23
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金面上项目（81473543）
- DOI：10.13422/j.cnki.syfjx.2018020019
  中图分类号： R286.0
- 纸质出版日期：2018
- 稿件说明：
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李超, 任晓亮, 王萌, 等. 复方血脂宁中4种药材对二苯乙烯苷稳定性的影响[J]. 中国实验方剂学杂志, 2018,24(2):19-23.

LI Chao, REN Xiao-liang, WANG Meng, et al. Effect of Four Medicinal Herbs on Stability of Stilbene Glucoside in Compound Xuezhining[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(2): 19-23.
李超, 任晓亮, 王萌, 等. 复方血脂宁中4种药材对二苯乙烯苷稳定性的影响[J]. 中国实验方剂学杂志, 2018,24(2):19-23. DOI： 10.13422/j.cnki.syfjx.2018020019.

LI Chao, REN Xiao-liang, WANG Meng, et al. Effect of Four Medicinal Herbs on Stability of Stilbene Glucoside in Compound Xuezhining[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(2): 19-23. DOI： 10.13422/j.cnki.syfjx.2018020019.

摘要

目的：考察复方血脂宁中4种药材提取液对二苯乙烯苷稳定性的影响，探究该复方的配伍规律。方法：采用UPLC考察不同条件下二苯乙烯苷单体及其在复方各药材提取液中含量随时间的变化规律，流动相甲醇（A）-0.1%甲酸水溶液（B）梯度洗脱（0~2 min，10%~25% A；2~9 min，25%~35% A；9~12 min，35%~40% A；12~40 min，40%~90% A），流速0.2 mL·min-1，柱温45℃，检测波长280 nm。利用化学反应动力学方法计算二苯乙烯苷在不同环境下的降解反应动力学参数，表征其半衰期（t1/2）和降解活化能。结果：二苯乙烯苷单体及其在不同药材提取液中的降解均遵循一级反应动力学规律，在pH 8.3条件下，二苯乙烯苷单体的降解速率常数（K）0.037 5 h-1，t1/2=18.48 h，该成分在山楂提取液中的K=0.012 3 h-1，t1/2=56.35 h，其他3种药材提取液也在不同条件下表现出对二苯乙烯苷的促稳作用。结论：复方血脂宁中药材配伍可不同程度地提高二苯乙烯苷的稳定性，其中以山楂效果最为显著，从稳定性角度探究了中药复方配伍的合理性。

Abstract

Objective:To study on the stability of stilbene glucoside in various extracts of medicinal materials from compound Xuezhining

and to explore compatibility rule of this compound. Method:The content of stilbene glucoside changed with time under different conditions was investigated by UPLC.Based on the chemical reaction kinetics

the parameters of degradation kinetics were calculated under different environments.The activation energy and half-time(t1/2) were investigated. Result:The degradations of stilbene glucoside in different conditions were followed the first-order reaction kinetics.The degradation rate constant (K) of stilbene glucoside in aqueous solution and Crataegi Fructus extract were 0.037 5

0.012 3 h-1

and t1/2 were 18.48

56.35 h under pH 8.3

respectively.The other extracts also showed the stabilizing effect on stilbene glucoside under different conditions. Conclusion:The compatibility of Chinese medicines in compound Xuezhining can improve the stability of stilbene glucoside in different degrees.Among them

effect of Crataegi Fructus is the most significant.

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