Objective: To study the clinical efficacy of modified Gegentang combined with spinal manipulation and its effect on inflammatory factors and pain mediators of cervical disc herniation (CDH). Method: Totally 157 cases of CDH patients treated in our hospital from March 2014 to December 2016 were selected and divided into two groups according to the admitted order

with 78 cases in clinical group and 79 in control group. Patients in control group were treated with spinal manipulation; in addition

the clinical group was also given modified Gegentang. Then the clinical efficacy

visual analogue scale/score (VAS) scores

inflammatory factors and pain mediators were compared. Result: Compared with 82.28% in the control group

the total effective rate of the clinical group was 94.87%

with significant differences (P<0.05). After the treatment for 6 d and 10 d

VAS scores of the two groups decreased

the experimental group was inferior to the control group (P<0.05). Compared with before treatment

tumor necrosis factor (TNF)-α

interleukin (IL)-1 and IL-6 of the two groups decreased after treatment (P<0.05). Compared with control group

the levels of TNF-α

IL-1 and IL-6 in patients of clinical group were lower after treatment (P<0.05). Compared with before treatment

5-hydroxytryptamine (5-HT)

prostaglandin (PEG2) and nitric oxide (NO) of the two groups decreased after treatment (P<0.05). Compared with control group

the levels of 5-HT

PEG2 and NO in patients of the clinical group were lower after treatment (P<0.05). Conclusion: Modified Gegentang combined with spinal manipulation can significantly enhance the therapeutic efficiency

lower VAS scores and the perception of pain

effectively inhibit inflammatory reaction and slow down the progress of cervical intervertebral disc degeneration. Therefore

it has a better effect on CDH and is worth clinical promotion and application.