Objective: To provide an effective way for processing evaluation and quality control of panaxadiol saponins(PDS)

Notoginseng Radix et Rhizoma and its ethanol extract

resin eluent by establishing the fingerprint of them. Method: HPLC was adopted to establish fingerprint of Notoginseng Radix et Rhizoma

PDS and their intermediates.The similarity evaluation was analyzed with similarity evaluation system for chromatograhic fingerprint of traditional Chinese medicine (2012 version).The processing of quality transmitting of components group was analyzed. Result: The components of PDS

Notoginseng Radix et Rhizoma and its ethanol extract

resin eluent could be well separated by the established HPLC.The developed method was precise

reproducible and stable.The similarities of the samples with their corresponding control fingerprint were ≥ 0.9. Sixteen common peaks were selected from 12 batches of Notoginseng Radix et Rhizoma

and 5 main peaks were identified.In the process

the panaxatriol saponins in the medicinal material was removed

while the PDS was transferred to PDS. Conclusion: The fingerprint method is stable and reliable

and it can fully demonstrate the changes of active materials of Notoginseng Radix et Rhizoma

panaxadiol saponins and their intermediate in the key production processes.