Objective: To study the efficacy of Wenyang Jianpi decoction combined with moxibustion and effect on recurrent oral ulcer (ROU) and its effect on inflammatory factor and Complement C3

C4. Method: A total of 132 cases of ROU patients treated in our hospital from January 2015 to June 2016 were selected and divided into two groups according to group sequential design

with 66 cases in each group. Patients in control group were treated with compound vitamin B

vitamin C and thoracic peptide gland; in addition to this therapy

the clinical group was also given Wenyang Jianpi decoction and moxibustion. Then

the treatment effect

the times of pain disappearance and oral ulcer healing

inflammatory factor and Complement C3

C4 were compared. Result: The total effective rate of clinical group was 95.45%

which was higher than 84.85% in control group. There was a significant increase (P<0.05). The times of pain disappearance and oral ulcer healing in clinical group were obviously shorter than that in control group (P<0.05). Compared with before treatment

interleukin (IL)-2 and tumor necrosis factor-α(TNF-α) of the two groups after treatment decreased

while IL-6 increased (P<0.05). Compared with control group

the levels of IL-2 and TNF-α in patients of experimental group were lower after treatment

while IL-6 was higher (P<0.05). Compared with before treatment

Complement C3 and C4 of two groups increased after treatment (P<0.05). Compared with control group

the levels in patients of experimental group were higher (P<0.05). Conclusion: Wenyang Jianpi decoction combined with moxibustion was very effective in treating ROU. It can significantly shorten the times of pain disappearance and oral ulcer healing

improve complement C3 and C4

with an apparent anti-inflammation effect

and thus is worthy of clinical promotion and application.