Objective: To observe the effect of Yiqi Huoxue Tongmai decoction on inflammatory cytokines and endothelial function in diabetic patients with atherosclerosis occlusion. Method: According to the random number method

104 cases of atherosclerosis occlusion treated in our hospital from April 2016 to August 2017 were divided into two groups. The control group (52 cases) was treated with conventional methods (including anticoagulation

anti-platelet aggregation

blood pressure lowering

blood glucose lowering

aerobic exercise

hyperbaric respiration

health massage). In addition to the therapy of the control group

the observation group (52 cases) was also treated with Yiqi Huoxue Tongmai decoction. After treatment

the efficacy of two groups was observed

and ankle/brachial index (ABI)

hemodynamic index

inflammatory factor and endothelial function of the two groups were observed. Result: Efficacy

after treatment

the total effective rate of the observation group was 96.15%

while the total effective rate of the control group was 84.62%

with statistically significant differences (χ2=3.983

P<0.05). ABI

after treatment

ABI in observation group was significantly greater than that in control group (P<0.05). Hemodynamics:after treatment

hemodynamics

ηb

ηp

erythrocyte electrophoresis (EEP)

erythrocyte sedimentation rate (ESR) and Fib of the observation group were significantly lower than those of the control group (P<0.05

P<0.01). Inflammatory cytokines

after treatment

interleukin (IL)-1

IL-6

tumor necrosis factor (TNF)-α and hypersensitive C-reactive protein (hs-CRP) of the observation group were significantly lower than those of the control group (P<0.05

P<0.01). Endothelial function

after treatment

endothelial lipase (EL)

endothlin-1 (ET-1) and monocyte chemo attractant protein-1 (MCP-1) of the observation group were significantly lower than those in control group (P<0.01)

and nitricoxide (NO) was significantly higher than that of control group (P<0.01). Conclusion: Yiqi Huoxue Tongmai decoction has a good effect in treatment of atherosclerosis occlusion

and can improve blood coagulation

stabilize hemodynamics

inhibit inflammatory response

and improve the function of endothelial cells.