消眩止晕片治疗颈性眩晕痰瘀内阻证的临床观察

董成林; 丁晶; 王晶; 丁玉峰

doi:10.13422/j.cnki.syfjx.20190632

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消眩止晕片治疗颈性眩晕痰瘀内阻证的临床观察

临床 | 更新时间：2021-02-09

- 消眩止晕片治疗颈性眩晕痰瘀内阻证的临床观察
- Clinical Efficacy of Xiaoxuan Zhiyun Tablet in Treating Cervical Vertigo with Syndrome of Phlegm and Blood Stasis Resistance
- 中国实验方剂学杂志 2019年25卷第6期页码：108-113
- 作者机构：
  
  华中科技大学　同济医学院　附属同济医院，武汉　 430030
- 作者简介：
  
  董成林，硕士，从事临床工作，E-mail：dong939948245@163.com
  丁玉峰，教授，硕士生导师，从事临床药学及药物新制剂研究工作，E-mail：yfding@tjh.tjmu.edu.cn
- 基金信息：
  
  湖北省自然科学基金项目(2013CFB162)
- DOI：10.13422/j.cnki.syfjx.20190632
  中图分类号： R25;R255;R255.3;R441;R441.2
- 收稿日期：2018-08-06，
  
  网络出版日期：2018-19-11，
  
  纸质出版日期：2019-03-20
- 稿件说明：
移动端阅览
董成林, 丁晶, 王晶, 等. 消眩止晕片治疗颈性眩晕痰瘀内阻证的临床观察[J]. 中国实验方剂学杂志, 2019,25(6):108-113.

Cheng-lin DONG, Jing DING, Jing WANG, et al. Clinical Efficacy of Xiaoxuan Zhiyun Tablet in Treating Cervical Vertigo with Syndrome of Phlegm and Blood Stasis Resistance[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(6): 108-113.
董成林, 丁晶, 王晶, 等. 消眩止晕片治疗颈性眩晕痰瘀内阻证的临床观察[J]. 中国实验方剂学杂志, 2019,25(6):108-113. DOI： 10.13422/j.cnki.syfjx.20190632.

Cheng-lin DONG, Jing DING, Jing WANG, et al. Clinical Efficacy of Xiaoxuan Zhiyun Tablet in Treating Cervical Vertigo with Syndrome of Phlegm and Blood Stasis Resistance[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(6): 108-113. DOI： 10.13422/j.cnki.syfjx.20190632.

摘要

目的：

探讨消眩止晕片治疗颈性眩晕痰瘀内阻证的疗效及对氧化应激和血清内皮素(ET)-1，5-羟色胺(5-HT)和一氧化氮(NO)水平的影响。

方法：

筛选符合要求就诊的颈性眩晕患者118例为研究对象，参照数字表法随机分为对照组和治疗组各59例。对照组采用正骨联合针刺治疗。治疗组在对照组治疗的基础上口服消眩止晕片，5片／次，3次/d。两组患者均进行3周的连续治疗。比较两组患者颈性眩晕症状与功能评估量表(ESCV)评分、眩晕障碍量表(DHI)评分、椎-基底动脉血流速度、生活质量及临床疗效。检测两组患者血清超氧化物歧化酶(SOD)，丙二醛(MDA)，ET-1，5-HT和NO水平。

结果：

治疗后，治疗组ESCV评分显著高于对照组，DHI评分明显低于对照组(

0.01)。治疗组治疗后患者左椎动脉、右椎动脉及基底动脉血流速度均显著高于对照组(

0.01)。治疗组患者的临床总有效率为98.25%，高于对照组的83.93%(

0.05)。治疗后，治疗组患者SF-36量表各项评分均显著高于对照组(

0.01)。治疗后，治疗组患者血清SOD，NO水平均显著高于对照组，MDA，ET-1和5-HT水平均明显低于对照组(

0.01)。

结论：

在正骨联合针刺治疗的基础上，加服消眩止晕片治疗颈性眩晕疗效显著，调节患者体内氧化应激及血清ET-1，5-HT和NO水平可能与其临床疗效有关。

Abstract

Objective:

To observe the efficacy of Xiaoxuan Zhiyun tablet in treating cervical vertigo with syndrome of phlegm and blood stasis resistance and its effect on oxidative stress and serum levels of endothelin-1(ET-1)

5-hydroxytryptamine (5-HT)

and nitric oxide (NO).

Method:

One hundred eighteen cervical vertigo cases were selected and randomly divided into control group (59 cases) and treatment group (59 cases) by random number table. Control group was given bone setting combined with acupuncture. In addition to the therapy of control group

treatment group was given Xiaoxuan Zhiyun tablet (1 dose/day

tid

). Both groups were treated for 3 weeks. Scores of cervical vertigo symptom and function assessment scale (ESCV) and vertigo disorder scale (DHI)

blood velocity of vertebrobasilar artery

life quality and efficacy were compared between both groups. Serum levels of superoxide dismutase (SOD)

malondialdehyde (MDA)

ET-1

5-HT and NO were detected in both groups.

Result:

After treatment

ESCV score of treatment group was obviously higher

while DHI score was lower than control group (

0.01). Blood flow velocity of left vertebral artery

right vertebral artery and basilar artery in treatment group were obviously higher than those of control group after treatment (

0.01). Total clinical efficacy of treatment group wsa 98.25%

which was superior to 83.93% of control group (

0.05). After treatment

SF-36 index score was remarkably higher than that of control group (

0.01). Serum levels of SOD and NO of treatment group were higher

while MDA

ET-1

5-HT were lower than control group (

0.01).

Conclusion:

In addition to the routine therapy

the efficacy of Xiaoxuan Zhiyun tablet in treating cervical vertigo is significant

which may be related with regulation of oxidative stress and serum levels of ET-1

5-HT and NO.

关键词

Keywords

references

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