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1.中国中医科学院 广安门医院,北京 100053
2.北京中医药大学,北京 100029
王阶,主任医师,教授,博士生导师,从事中西医结合心血管病防治研究,Tel:010-88001229,E-mail:wangjie0103@126.com
陈光,在读博士,从事中西医结合心血管病防治研究,E-mail:0901085@bucm.edu.cn
收稿日期:2018-12-10,
网络出版日期:2018-12-14,
纸质出版日期:2019-01-05
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王阶, 陈光. 基于复杂系统的冠心病痰瘀滞虚理论及临证应用[J]. 中国实验方剂学杂志, 2019,25(1):11-15.
Jie WANG, Guang CHEN. Coronary Heart Disease Phlegm-blood Stasis-stagnation-deficiency Innovation Theory and Clinical Application Based on Complex System[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(1): 11-15.
王阶, 陈光. 基于复杂系统的冠心病痰瘀滞虚理论及临证应用[J]. 中国实验方剂学杂志, 2019,25(1):11-15. DOI: 10.13422/j.cnki.syfjx.20190750.
Jie WANG, Guang CHEN. Coronary Heart Disease Phlegm-blood Stasis-stagnation-deficiency Innovation Theory and Clinical Application Based on Complex System[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(1): 11-15. DOI: 10.13422/j.cnki.syfjx.20190750.
冠心病的中医治疗历史上经历了温阳散寒、行气化痰、活血化瘀的变化趋势,其时空发展符合复杂系统理论。针对现代冠心病人群,创新性提出痰瘀滞虚理论,以指导临床提高疗效。理论方面,瘀滞是冠心病的疾病基本病机,贯穿冠心病病程的始终;痰这一要素随社会的发展已经并且仍在深刻地改变冠心病患者人群的证候特点;从冠心病虚的病理基础入手进行补养,可以延缓衰老过程,推迟疾病发生,延缓疾病进展,是中医区别于现代医学,发挥自身优势,解决冠心病难题的核心要旨。基于此,临证方面,冠心病的治疗应以活血化瘀通滞为疾病的基本治法,冠心2号方、血府逐瘀汤、栀子豉汤、当归拈痛汤可供冠心病不同阶段使用;通过药物的补养,调整身体的状态,从而预防冠心病发生以及延缓冠心病进展,如党参、黄芪、六味地黄丸、左归饮、右归饮均为补益佳品;香类药物既可化痰通脉止痛,又可宁心安神,消除冠心病患者紧张情绪,如沉香、檀香、麝香在冠心病治疗中均可得以妙用。
There exits a trend of treatment for coronary heart disease(CHD) in terms of Chinese medicine(CM) in history
from warming Yang and dispelling cold
moving Qi and dissolving phlegm to invigorating blood and dissolving stasis
whose time-space development accords to the theory of complex system.Targeting the contemporary population of CHD
phlegm-blood stasis-stagnation-deficiency theory is proposed to direct clinical application to further improve effectiveness.From the perspective of theory
blood stasis-stagnation is the basic pathogenesis of CHD that runs through the whole period in the advance of CHD
while phlegm has been changing the feature of CM Zheng of CHD population with the development of the society
and nourishing the body according to the type of deficiency might delay the process of growing older
postpone the occur of disease and hinder the advance of disease
which genuinely differs from modern medicine to render the superiority of CM to work out the challenges of CHD.As for the clinical application
the treatment options could consider invigorating blood
dissolving stasis and removing stagnation as the basic method
such as CHD formula 2
Xuefu Zhuyutang
Zhizi Chitang and Danggui Niantongtang could be used in varied period of CHD.Moreover
boosting the body by herbal medicine could regulate the routine of body
then to prevent CHD and fear down the advance of CHD
for instance
Codonopsis Radix
Astragali Radix
Liuwei Dihuang pills
Zuoguiyin and Youguiyin.Furthermore
balmiest herbs could not only dissolve phlegm
unblock the meridian and relieve pain
but also calm the mind and eliminate the anxiety.For example
Aquilariae Lignum Resinatum
Santali Albi Lignum and Moschus could be used handily in the treatment of CHD.
李柳骥 . 冠心病心绞痛古今中医文献整理与研究 [D]. 北京 : 北京中医药大学 , 2007 .
王阶 , 王永炎 . 复杂系统理论与中医方证研究 [J]. 中国中医药信息杂志 , 2001 , 8 ( 9 ): 25 - 27 .
O'Gara P T , Kushner F G , Ascheim D D ,et al . 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction:a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines [J]. J Am Coll Cardiol , 2013 , 61 ( 4 ): e78 - e140 .
陆再英 , 钟南山 . 内科学 [M]. 7版 . 北京 : 人民卫生出版社 , 2008 : 267 .
Whelton P K , Carey R M , Aronow W S ,et al . 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention,detection,evaluation,and management of high blood pressure in adults:a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines [J]. Circulation , 2018 , 138 ( 17 ): e484 - e594 .
International Diabetes Federation Guideline Development Group . Global guideline for type 2 diabetes [J]. Diabetes Res Clin Pract , 2014 , 104 ( 1 ): 1 - 52 .
Robinson J G , Stone N J. The 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk:a new paradigm supported by more evidence [J]. Eur Heart J , 2015 , 36 ( 31 ): 2110 - 2118 .
Fouquerel E , Lormand J , Bose A ,et al . Oxidative guanine base damage regulates human telomerase activity [J]. Nat Struct Mol Biol , 2016 , 23 ( 12 ): 1092 - 1100 .
Kubben N , ZHANG W , WANG L ,et al . Repression of the antioxidant NRF2 pathway in premature aging [J]. Cell , 2016 , 165 ( 6 ): 1361 - 1374 .
中华中医药学会心血管病分会 . 冠心病稳定型心绞痛中医诊疗专家共识 [J]. 中医杂志 , 2018 , 59 ( 5 ): 447 - 450 .
PAN C , LOU L , HUO Y ,et al . Salvianolic acid B and tanshinone Ⅱ A attenuate myocardial ischemia injury in mice by NO production through multiple pathways [J]. Ther Adv Cardiovasc Dis , 2011 , 5 ( 2 ): 99 - 111 .
XU W , YANG J , WU L M. Cardioprotective effects of tanshinone Ⅱ A on myocardial ischemia injury in rats [J]. Pharmazie , 2009 , 64 ( 5 ): 332 - 336 .
Maione F , Cantone V , Chini M G ,et al . Molecular mechanism of tanshinone Ⅱ A and cryptotanshinone in platelet anti-aggregating effects:an integrated study of pharmacology and computational analysis [J]. Fitoterapia , 2015 , 100 : 174 - 178 .
ZHOU Z Y , HUANG B , LI S ,et al . Sodium tanshinone Ⅱ A sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish [J]. Toxicol Appl Pharmacol , 2018 , 350 : 32 - 42 .
ZHAO D , TONG L , ZHANG L ,et al . Tanshinone Ⅱ A stabilizes vulnerable plaques by suppressing RAGE signaling and NF- κ B activation in apolipoprotein-E-deficient mice [J]. Mol Med Rep , 2016 , 14 ( 6 ): 4983 - 4990 .
HU H , ZHAI C , QIAN G ,et al . Protective effects of tanshinone Ⅱ A on myocardial ischemia reperfusion injury by reducing oxidative stress,HMGB1 expression, and inflammatory reaction [J]. Pharm Biol , 2015 , 53 ( 12 ): 1752 - 1758 .
魏毅 , 张贵平 . 白芍总苷对血小板功能的影响 [J]. 医学理论与实践 , 2004 , 17 ( 8 ): 871 - 872 .
LIU C , WANG J , YANG J. Study on activating blood and eliminating stasis of total paeony glycoside(TPG) [J]. J Chin Med Mater , 2000 , 23 ( 9 ): 557 - 560 .
LONG J , GAO M , KONG Y ,et al . Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats [J]. Phytomedicine , 2012 , 19 ( 8/9 ): 672 - 676 .
LI J , CHEN C X , SHEN Y H. Effects of total glucosides from paeony( Paeonia lactiflora Pall) roots on experimental atherosclerosis in rats [J]. J Ethnopharmacol , 2011 , 135 ( 2 ): 469 - 475 .
Kim E Y , Kim J H , Rhyu M R. Endothelium-independent vasorelaxation by Ligusticum wallichii in isolated rat aorta:comparison of a butanolic fraction and tetramethylpyrazine,the main active component of Ligusticum wallichii [J]. Biol Pharm Bull , 2010 , 33 ( 8 ): 1360 - 1363 .
Kim B , Kim J , Kim A ,et al . Ligusticum wallichi -induced vasorelaxation mediated by mitogen-activated protein kinase in rat aortic smooth muscle [J]. J Ethnopharmacol , 2004 , 90 ( 2/3 ): 397 - 401 .
PANG P K , SHAN J J , Chiu K W. Tetramethylpyrazine,a calcium antagonist [J]. Planta Med , 1996 , 62 ( 5 ): 431 - 435 .
Kim E Y , Rhyu M R. Synergistic vasorelaxant and antihypertensive effects of Ligusticum wallichii ,and Angelica gigas [J]. J Ethnopharmacol , 2010 , 130 ( 3 ): 545 - 551 .
汪昂 . 医方集解 [M]. 北京 : 人民卫生出版社 , 2006 : 246 .
冯彬彬 , 张建海 . 党参不同配伍研究进展 [J]. 中国实验方剂学杂志 , 2016 , 22 ( 19 ): 194 - 198 .
靳如娜 , 齐晓甜 , 孙蓉 , 等 . 经典名方当归补血汤的药效物质基础和质量控制研究进展 [J]. 中国实验方剂学杂志 , 2018 , doi: 10.13422/j.cnki.syfjx.20190648 http://doi.org/10.13422/j.cnki.syfjx.20190648 .
李时珍 . 本草纲目 [M]. 北京 : 华夏出版社 , 2002 : 1301,1306,1877 .
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