浏览全部资源
扫码关注微信
橘黄裸伞子实体中的多异戊二烯多醇类化合物分离鉴定
Polyisoprenepolyols from Fruiting Bodies of
Gymnopilus spectabilis - 中国实验方剂学杂志 2019年25卷第20期 页码：121-124
- 作者机构：
1.大理大学 药学与化学学院，云南 大理 671000；
2.大理大学 公共卫生学院，云南 大理 671000
- 作者简介：
王双，博士，讲师，从事高等真菌化学研究工作，Tel: 0872-2257411，E-mail: wangshuang@dali.edu.cn
- 基金信息：大理大学中药资源与民族药创新团队项目(ZKLX2019318);云南省科技厅青年项目(KY1713102940)
DOI：10.13422/j.cnki.syfjx.20192015
中图分类号： R284.2收稿日期：2019-05-23，
网络出版日期：2019-07-09，
纸质出版日期：2019-10-20
- 稿件说明：
移动端阅览
王双, 宋艳秋. 橘黄裸伞子实体中的多异戊二烯多醇类化合物分离鉴定[J]. 中国实验方剂学杂志, 2019,25(20):121-124.
Shuang WANG, Yan-qiu SONG. Polyisoprenepolyols from Fruiting Bodies of
Gymnopilus spectabilis [J]. Chinese journal of experimental traditional medical formulae, 2019, 25(20): 121-124.王双, 宋艳秋. 橘黄裸伞子实体中的多异戊二烯多醇类化合物分离鉴定[J]. 中国实验方剂学杂志, 2019,25(20):121-124. DOI： 10.13422/j.cnki.syfjx.20192015.
Shuang WANG, Yan-qiu SONG. Polyisoprenepolyols from Fruiting Bodies of
Gymnopilus spectabilis [J]. Chinese journal of experimental traditional medical formulae, 2019, 25(20): 121-124. DOI： 10.13422/j.cnki.syfjx.20192015.
摘要
目的：
2
发现更多的高等真菌次级代谢产物，研究法国野生致幻真菌橘黄裸伞
Gymnopilus spectabilis
子实体的化学成分。
方法：
2
采用常压硅胶柱色谱、凝胶色谱和中压液相色谱、制备高效液相色谱等手段对橘黄裸伞子实体的三氯甲烷-丙酮-甲醇(1∶1∶1)提取物进行分离纯化，利用核磁共振波谱和高分辨质谱等方法鉴定化合物结构。
结果：
2
从法国野生真菌橘黄裸伞子实体中分离得到了6个多异戊二烯多醇类化合物，分别是gymnopilene A (1)，hypsiziprenol B
10
，A
10
，A
11
(2～4)，gymnopilin A
10
，3a(5，6)。
结论：
2
化合物
1
为新化合物，命名为gymnopilene A。化合物
1～4
为首次从橘黄裸伞中分离得到。
Abstract
Objective:
2
To study the chemical constituents
especially hallucinogenic substances of fruiting bodies of
Gymnopilus spectabilis
from France.
Method:
2
The fruiting bodies of
G
.
spectabilis
were extracted with chloroform-acetone-methanol (1∶1∶1)
then the compounds were isolated and purified by silica gel column chromatography
gel chromatography
MPLC and preparative HPLC. Their structures were identified by spectroscopic analysis methods
such as 1D-NMR
2D-NMR and MS.
Result:
2
Six polyisoprenepolyols compounds were isolated and identified from fruiting bodies of
G
.
spectabilis
namely gymnopilene A (1)
hypsiziprenol B
10
A
10
A
11
(2-4)
ymnopilin A
10
3a(5-6).
Conclusion:
2
Compound 1is a new compound that is named gymnopilene A
and compounds 1-4are isolated from G.
spectabilis
for the first time.
关键词
Keywords
references
Smith A H . Mushrooms in their natural habitats [M]. Portland : Sawyers Inc , 1949 : 471 .
CHEN J B , LI M J , YAN X T , et al . Determining the pharmacokinetics of psilocin in rat plasma using ultra-performance liquid chromatography coupled with a photodiode array detector after orally administering an extract of Gymnopilus spectabilis [J]. J Chromatogr B , 2011 , 879 ( 25 ): 2669 - 2672 .
Hatifield G M , Valdes L J . The occurrence of psilocybin in Gymnopilus species [J]. Lloydia , 1978 , 41 ( 2 ): 140 - 144 .
Tanaka M , Hashimoto K , Okuno T , et al . Neurotoxic oligoisoprenoids of the hallucinogenic mushroom, Gymnopilus spectabilis [J]. Phytochemistry , 1993 , 34 ( 3 ): 661 - 664 .
Findlay J A , HE Z Q . Minor constituents of Gymnopilus spectabilis [J]. J Nat Prod , 1991 , 54 ( 1 ): 184 - 189 .
Kim K H , Choi S U , Lee K R . Gymnopilin K: a new cytotoxic gymnopilin from Gymnopilus spectabilis [J]. J Antibiot , 2011 , 65 ( 3 ): 135 - 137 .
Kayano T , Kitamura N , Miyazaki S , et al . Gymnopilins, a product of a hallucinogenic mushroom, inhibit the nicotinic acetylcholine receptor [J]. Toxicon , 2014 , 81 ( C ): 23 - 31 .
Akihisa T , Franzblau S G , Tokuda H , et al . Antitubercular activity and inhibitory effect on Epstein-Barr virus activation of sterols and polyisoprenepolyols from an edible mushroom, Hypsizigus marmoreus [J]. Biol Pharm Bull , 2005 , 28 ( 6 ): 1117 - 1119 .
Sawabe A , Morita M , Ouchi S , et al . Fast atom bombardment mass spectrometry and linked scan analyses at constant B/E in the structural characterizaton of new polyisoprenepolyols isolated from an edible mushroom(Hypsizigus marmoreus) [J]. J Mass Spectrom , 1996 , 31 ( 8 ): 921 - 925 .
Sawabe A , Morita M , Kiso T , et al . Structural analyses of a precursory substance of bitterness: New polyisoprenepolyols isolated from an edible mushroom (Hypsizigus marmoreus) by fast atom bombardment mass spectrometry [J]. J Agric Food Chem , 1999 , 47 ( 2 ): 588 - 593 .
Lee I K , Cho S M , Seok S J , et al . Chemical constituents of Gymnopilus spectabilis and their antioxidant activity [J]. Mycobiology , 2008 , 36 ( 1 ): 55 - 59 .
Suha W S , Leea S R , Kima C S , et al . A new monoacylglycerol from the fruiting bodies of Gymnopilus spectabilis [J]. J Chem Res , 2016 , 47 ( 30 ): 156 - 159 .
Alborés S , Mora P , Bustamante M J , et al . Purification and applications of a lectin from the mushroom Gymnopilus spectabilis [J]. Appl Biochem Biotechnol , 2014 , 172 ( 4 ): 2081 - 2090 .
Aoyagi F , Maeno S , Okuno T , et al . Gymnopilins, bitter principles of the big-laughter mushroom Gymnopilus spectabilis [J]. Tetrahedron Lett , 1983 , 24 ( 13 ): 1991 - 1994 .
Nakagiri A . Collection, preservation and practical use of mushroom genetic resources [J]. Bio Resource Now , 2014 , 10 ( 9 ): 1 - 2 .
0
浏览量
13
下载量
2
CSCD
- 网络PDF下载
- BibTeX下载
- Endnote下载
- RefMan 下载
- NoteExpress下载
- NoteFirst下载
关联资源
相关文章
相关作者
相关机构
AI问答- 地址：北京市东城区东直门内南小街16号 邮编：100700
- 联系电话：010-84076882 Email：syfjx_2010@188.com
- 技术支持由北京北大方正电子有限公司提供 京ICP备11006657号-10
京公网安备11010802024621 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies
